Expression of supreoxide dismutase and catalase in rat brain as a function of age

Imre Semsei, Govinda Rao, Arlan Richardson

Research output: Contribution to journalArticlepeer-review

96 Scopus citations

Abstract

Active oxygen species have been proposed to be involved in the aging process of the brain, therefore alterations of the levels of enzymes involved in the defence system against free radicals and other active species could substantially influence the aging process. In this study the enzyme activities of superoxide dismutase (Cu/Zn) and caatalase as well as the relative levels of their mRNA were measured in the brain of Fischer F344 rats of various ages (5-37 months old). A gradual decrease in the activity of these enzymes (21-27%) was observed with increasing age. The alterations were paralleled by a decrease (39-40%) in the relative levels of these mRNA species. Thus the decrease in the activity of superoxide dismutase and catalase appears to be due to an age-dependent change in the expression of these genes.

Original languageEnglish (US)
Pages (from-to)13-19
Number of pages7
JournalMechanisms of Ageing and Development
Volume58
Issue number1
DOIs
StatePublished - Apr 1 1991

Keywords

  • Aging
  • Brain
  • Catalase
  • Gene expression
  • Superoxide dismutase

ASJC Scopus subject areas

  • Aging
  • Developmental Biology

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