Abstract
Ubiquitin and alpha B-crystallin belong to a class of proteins which are overexpressed in a variety of human neuropathological conditions associated with increased cellular stress. In this study we have examined the brains of aged rhesus monkeys (Macaca mulatta; n = 10, mean age: 29.7 years) using antibodies against the stress proteins ubiquitin, alpha B-crystallin, and heat shock protein 27 (hsp27). Here, we demonstrate an increased expression of ubiquitin, alpha B-crystallin, and hsp27 in spheroid bodies predominantly localized in the globus pallidus and pars reticulata of the substantia nigra. A portion of the pallido-nigral spheroids also contained ferric iron as highlighted by Perls' staining. On the basis of these findings we advance the hypothesis that expression of ubiquitin, alpha B-crystallin, and hsp27 in pallido-nigral spheroids of aged rhesus monkeys represents a stress response possibly related to increased iron-mediated oxidative stress.
Original language | English (US) |
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Pages (from-to) | 677-682 |
Number of pages | 6 |
Journal | Neurobiology of Aging |
Volume | 22 |
Issue number | 4 |
DOIs | |
State | Published - 2001 |
Keywords
- Alpha B-crystallin
- Hallervorden-Spatz disease
- Heat shock proteins
- Iron
- Nonhuman primates
- Oxidative stress
- Parkinson's disease
- Spheroids
- Ubiquitin
ASJC Scopus subject areas
- Neuroscience(all)
- Aging
- Clinical Neurology
- Developmental Biology
- Geriatrics and Gerontology