Expression of stress proteins alpha B-crystallin, ubiquitin, and hsp27 in pallido-nigral spheroids of aged rhesus monkeys

Christian Schultz, Edward J. Dick, Ann B. Cox, Gene B. Hubbard, Eva Braak, Heiko Braak

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Ubiquitin and alpha B-crystallin belong to a class of proteins which are overexpressed in a variety of human neuropathological conditions associated with increased cellular stress. In this study we have examined the brains of aged rhesus monkeys (Macaca mulatta; n = 10, mean age: 29.7 years) using antibodies against the stress proteins ubiquitin, alpha B-crystallin, and heat shock protein 27 (hsp27). Here, we demonstrate an increased expression of ubiquitin, alpha B-crystallin, and hsp27 in spheroid bodies predominantly localized in the globus pallidus and pars reticulata of the substantia nigra. A portion of the pallido-nigral spheroids also contained ferric iron as highlighted by Perls' staining. On the basis of these findings we advance the hypothesis that expression of ubiquitin, alpha B-crystallin, and hsp27 in pallido-nigral spheroids of aged rhesus monkeys represents a stress response possibly related to increased iron-mediated oxidative stress.

Original languageEnglish (US)
Pages (from-to)677-682
Number of pages6
JournalNeurobiology of Aging
Volume22
Issue number4
DOIs
StatePublished - Jul 14 2001
Externally publishedYes

Keywords

  • Alpha B-crystallin
  • Hallervorden-Spatz disease
  • Heat shock proteins
  • Iron
  • Nonhuman primates
  • Oxidative stress
  • Parkinson's disease
  • Spheroids
  • Ubiquitin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

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