Expression of sialylated Lewis(x) antigen in chronic and neoplastic liver diseases

J. Jagirdar, S. N. Thung, K. D. Shah, E. Nudelman, A. Singhal, F. Paronetto

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Phenotypic expression of sialylated Lewis(x) antigen by means of the monoclonal antiserum SNH3 was studied in 87 livers, which included normal and steatotic livers and livers with chronic persistent and chronic active hepatitis, alcoholic hepatitis, allograft rejection, focal nodular hyperplasia, hepatocellular carcinoma, cholangiocarcinoma, metastatic carcinoma, cirrhosis of various causes (autoimmune, alcoholic, viral, drug induced, Wilson's disease, and primary biliary cirrhosis). The biotin- streptavidin-peroxidase method was used on formaldehyde-fixed, paraffin- embedded sections. Sialylated Lewis(x) antigen was not demonstrated in normal livers. Hepatocellular expression in a diffuse or perinodular honeycomb pattern was seen in cirrhosis, irrespective of cause. Sialylated Lewis(x) antigen was also observed in hepatocytes around metastatic carcinoma in the absence of inflammation, cirrhosis, or regeneration. Some bile ductules, most likely ductular hepatocytes, but not bile ducts, expressed sialylated Lewis(x) antigen. Sialylated Lewis(x) antigen was seen diffusely in fibrolamellar hepatocellular carcinoma, focally in other hepatocellular carcinomas, and either focally or diffusely in cholangiocarcinomas.

Original languageEnglish (US)
Pages (from-to)643-648
Number of pages6
JournalArchives of Pathology and Laboratory Medicine
Volume116
Issue number6
StatePublished - 1992
Externally publishedYes

Fingerprint

Liver Diseases
Antigens
Fibrosis
Cholangiocarcinoma
Liver
Hepatocytes
Hepatocellular Carcinoma
Focal Nodular Hyperplasia
Alcoholic Hepatitis
Carcinoma
Hepatolenticular Degeneration
Streptavidin
Biliary Liver Cirrhosis
Chronic Hepatitis
Biotin
Bile Ducts
Bile
Paraffin
Formaldehyde
Peroxidase

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

Cite this

Jagirdar, J., Thung, S. N., Shah, K. D., Nudelman, E., Singhal, A., & Paronetto, F. (1992). Expression of sialylated Lewis(x) antigen in chronic and neoplastic liver diseases. Archives of Pathology and Laboratory Medicine, 116(6), 643-648.

Expression of sialylated Lewis(x) antigen in chronic and neoplastic liver diseases. / Jagirdar, J.; Thung, S. N.; Shah, K. D.; Nudelman, E.; Singhal, A.; Paronetto, F.

In: Archives of Pathology and Laboratory Medicine, Vol. 116, No. 6, 1992, p. 643-648.

Research output: Contribution to journalArticle

Jagirdar, J, Thung, SN, Shah, KD, Nudelman, E, Singhal, A & Paronetto, F 1992, 'Expression of sialylated Lewis(x) antigen in chronic and neoplastic liver diseases', Archives of Pathology and Laboratory Medicine, vol. 116, no. 6, pp. 643-648.
Jagirdar J, Thung SN, Shah KD, Nudelman E, Singhal A, Paronetto F. Expression of sialylated Lewis(x) antigen in chronic and neoplastic liver diseases. Archives of Pathology and Laboratory Medicine. 1992;116(6):643-648.
Jagirdar, J. ; Thung, S. N. ; Shah, K. D. ; Nudelman, E. ; Singhal, A. ; Paronetto, F. / Expression of sialylated Lewis(x) antigen in chronic and neoplastic liver diseases. In: Archives of Pathology and Laboratory Medicine. 1992 ; Vol. 116, No. 6. pp. 643-648.
@article{d26f4997488e407daaef3d91931564f5,
title = "Expression of sialylated Lewis(x) antigen in chronic and neoplastic liver diseases",
abstract = "Phenotypic expression of sialylated Lewis(x) antigen by means of the monoclonal antiserum SNH3 was studied in 87 livers, which included normal and steatotic livers and livers with chronic persistent and chronic active hepatitis, alcoholic hepatitis, allograft rejection, focal nodular hyperplasia, hepatocellular carcinoma, cholangiocarcinoma, metastatic carcinoma, cirrhosis of various causes (autoimmune, alcoholic, viral, drug induced, Wilson's disease, and primary biliary cirrhosis). The biotin- streptavidin-peroxidase method was used on formaldehyde-fixed, paraffin- embedded sections. Sialylated Lewis(x) antigen was not demonstrated in normal livers. Hepatocellular expression in a diffuse or perinodular honeycomb pattern was seen in cirrhosis, irrespective of cause. Sialylated Lewis(x) antigen was also observed in hepatocytes around metastatic carcinoma in the absence of inflammation, cirrhosis, or regeneration. Some bile ductules, most likely ductular hepatocytes, but not bile ducts, expressed sialylated Lewis(x) antigen. Sialylated Lewis(x) antigen was seen diffusely in fibrolamellar hepatocellular carcinoma, focally in other hepatocellular carcinomas, and either focally or diffusely in cholangiocarcinomas.",
author = "J. Jagirdar and Thung, {S. N.} and Shah, {K. D.} and E. Nudelman and A. Singhal and F. Paronetto",
year = "1992",
language = "English (US)",
volume = "116",
pages = "643--648",
journal = "Archives of Pathology and Laboratory Medicine",
issn = "0003-9985",
publisher = "College of American Pathologists",
number = "6",

}

TY - JOUR

T1 - Expression of sialylated Lewis(x) antigen in chronic and neoplastic liver diseases

AU - Jagirdar, J.

AU - Thung, S. N.

AU - Shah, K. D.

AU - Nudelman, E.

AU - Singhal, A.

AU - Paronetto, F.

PY - 1992

Y1 - 1992

N2 - Phenotypic expression of sialylated Lewis(x) antigen by means of the monoclonal antiserum SNH3 was studied in 87 livers, which included normal and steatotic livers and livers with chronic persistent and chronic active hepatitis, alcoholic hepatitis, allograft rejection, focal nodular hyperplasia, hepatocellular carcinoma, cholangiocarcinoma, metastatic carcinoma, cirrhosis of various causes (autoimmune, alcoholic, viral, drug induced, Wilson's disease, and primary biliary cirrhosis). The biotin- streptavidin-peroxidase method was used on formaldehyde-fixed, paraffin- embedded sections. Sialylated Lewis(x) antigen was not demonstrated in normal livers. Hepatocellular expression in a diffuse or perinodular honeycomb pattern was seen in cirrhosis, irrespective of cause. Sialylated Lewis(x) antigen was also observed in hepatocytes around metastatic carcinoma in the absence of inflammation, cirrhosis, or regeneration. Some bile ductules, most likely ductular hepatocytes, but not bile ducts, expressed sialylated Lewis(x) antigen. Sialylated Lewis(x) antigen was seen diffusely in fibrolamellar hepatocellular carcinoma, focally in other hepatocellular carcinomas, and either focally or diffusely in cholangiocarcinomas.

AB - Phenotypic expression of sialylated Lewis(x) antigen by means of the monoclonal antiserum SNH3 was studied in 87 livers, which included normal and steatotic livers and livers with chronic persistent and chronic active hepatitis, alcoholic hepatitis, allograft rejection, focal nodular hyperplasia, hepatocellular carcinoma, cholangiocarcinoma, metastatic carcinoma, cirrhosis of various causes (autoimmune, alcoholic, viral, drug induced, Wilson's disease, and primary biliary cirrhosis). The biotin- streptavidin-peroxidase method was used on formaldehyde-fixed, paraffin- embedded sections. Sialylated Lewis(x) antigen was not demonstrated in normal livers. Hepatocellular expression in a diffuse or perinodular honeycomb pattern was seen in cirrhosis, irrespective of cause. Sialylated Lewis(x) antigen was also observed in hepatocytes around metastatic carcinoma in the absence of inflammation, cirrhosis, or regeneration. Some bile ductules, most likely ductular hepatocytes, but not bile ducts, expressed sialylated Lewis(x) antigen. Sialylated Lewis(x) antigen was seen diffusely in fibrolamellar hepatocellular carcinoma, focally in other hepatocellular carcinomas, and either focally or diffusely in cholangiocarcinomas.

UR - http://www.scopus.com/inward/record.url?scp=0026634013&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026634013&partnerID=8YFLogxK

M3 - Article

C2 - 1352099

AN - SCOPUS:0026634013

VL - 116

SP - 643

EP - 648

JO - Archives of Pathology and Laboratory Medicine

JF - Archives of Pathology and Laboratory Medicine

SN - 0003-9985

IS - 6

ER -