Expression of PGK-A in the Australian brush-tailed possum, Trichosurus vulpecula (Kerr), consistent with paternal X inactivation

J. L. VandeBerg, J. E. Thiel, R. M. Hope, D. W. Cooper

    Research output: Contribution to journalArticlepeer-review

    9 Scopus citations

    Abstract

    An extensive survey of erythrocytes of marsupials other than kangaroos for electrophoretic variation in X-linked enzymes revealed two rare PGK-A phenotypes in the phalangerid Trichosurus vulpecula and one in Trichosurus caninus. Four putatively heterozygous females expressed only the variant allelic isozyme in some tissues but expressed a trace of the normal isozyme in others. A putatively hemizygous male expressed only the variant isozyme in all tissues. The phenotypic patterns were consistent with those observed in kangaroos known to exhibit partial or complete paternal X inactivation in cells of females. Two of the T. vulpecula were a mother and her female pouch young, further suggesting that paternal X inactivation occurs in T. vulpecula. This peculiar mechanism of dosage compensation may not be restricted to kangaroos.

    Original languageEnglish (US)
    Pages (from-to)325-332
    Number of pages8
    JournalBiochemical Genetics
    Volume17
    Issue number3-4
    DOIs
    StatePublished - Apr 1979

    Keywords

    • dosage compensation
    • isozymes
    • marsupial
    • paternal X inactivation
    • phosphoglycerate kinase (PGK)

    ASJC Scopus subject areas

    • Ecology, Evolution, Behavior and Systematics
    • Biochemistry
    • Molecular Biology
    • Genetics

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