Expression of cloned β-endorphin gene sequences by Escherichia coli

John Shine, Ivy Fettes, Nancy C.Y. Lan, James L. Roberts, John D. Baxter

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

DNA coding for the opiate peptide β-endorphin has been cloned into bacterial plasmids in such a way as to direct the synthesis of a hybrid β-galactosidase/β-endorphin protein. This hybrid protein can readily be cleaved in vitro to release biologically active β-endorphin.

Original languageEnglish (US)
Pages (from-to)456-461
Number of pages6
JournalNature
Volume285
Issue number5765
DOIs
StatePublished - Dec 1 1980
Externally publishedYes

ASJC Scopus subject areas

  • General

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