Expression of CD4 on peripheral blood granulocytes: A novel finding in a case of myelodysplastic syndrome in association with t(5;12)

M. Tarek Elghetany, Claudia P. Molina, Jyoti Patel, Joe Martinez, Hanna Schwab, Gopalrao V Velagaleti

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Myelodysplastic syndromes (MDS) are associated with cell maturation defects that can manifest as abnormal surface antigen expression. We describe a patient with refractory anemia with excess blasts, who presented with infection and extensive dysplastic features in peripheral blood granulocytes. The granulocytes expressed CD11b, CD13, CD15, CD33, and CD43. The granulocytes also expressed CD4 antigen. Cytogenetic analysis showed a clonal t(5;12)(q33;p13). The patient improved on antibiotics with partial improvement in the dysplastic features. However, shortly after, the patient experienced paravertebral extramedullary blast transformation followed by a leukemia phase of acute monoblastic leukemia. The patient died a few days later. This is the first report describing anomalous expression of CD4 on granulocytes in MDS. Since the breakpoint on chromosome 12 is near the CD4 gene, which is mapped to 12p12, we hypothesize that dysregulation of the CD4 gene may have occurred resulting in its persistent expression on mature and maturing granulocytes.

Original languageEnglish (US)
Pages (from-to)38-42
Number of pages5
JournalCancer Genetics and Cytogenetics
Volume136
Issue number1
DOIs
StatePublished - Jul 1 2002
Externally publishedYes

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Myelodysplastic Syndromes
Granulocytes
Leukemia, Monocytic, Acute
Refractory Anemia with Excess of Blasts
Chromosomes, Human, Pair 12
CD4 Antigens
Cytogenetic Analysis
Surface Antigens
Lymphocyte Activation
Genes
Leukemia
Anti-Bacterial Agents
Infection

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Expression of CD4 on peripheral blood granulocytes : A novel finding in a case of myelodysplastic syndrome in association with t(5;12). / Elghetany, M. Tarek; Molina, Claudia P.; Patel, Jyoti; Martinez, Joe; Schwab, Hanna; Velagaleti, Gopalrao V.

In: Cancer Genetics and Cytogenetics, Vol. 136, No. 1, 01.07.2002, p. 38-42.

Research output: Contribution to journalArticle

Elghetany, M. Tarek ; Molina, Claudia P. ; Patel, Jyoti ; Martinez, Joe ; Schwab, Hanna ; Velagaleti, Gopalrao V. / Expression of CD4 on peripheral blood granulocytes : A novel finding in a case of myelodysplastic syndrome in association with t(5;12). In: Cancer Genetics and Cytogenetics. 2002 ; Vol. 136, No. 1. pp. 38-42.
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