Expression of c-erbb-2 in in situ and in adjacent invasive ductal adenocarcinomas of the female breast

H. C. Maguire, M. E. Hellman, M. I. Greene, I. Yeh

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Several lines of evidence have demonstrated that expression of the c-erbB-2 gene product contributes to the malignant phenotype. We and others have determined that c-erbB-2 is substantially expressed in most ductal in situ carcinomas of the comedo type, but not in other patterns of ductal carcinoma in situ or in atypical ductal hyperplasia of the breast. In the present investigation, by immunohistochemistry we inquired whether invasive ductal adenocarcinomas retained the c-erbB-2 expression status of the in situ carcinomas from which they derived. Of twelve specimens containing both cribriform/micro- papillary in situ and derivative invasive adenocarcinomas in the same section, all tumor cells were negative for c-erbB-2 expression. In thirteen in situ carcinomas of the comedo type, with identifiable invasive components, ten had definite c-erbB-2 expression, and in every case there was comparable c-erbB-2 protein staining of in situ and invasive components; in three of these ten cases the staining in the in situ component tended to be more intense. These findings imply that a significant proportion of invasive mammary adenocarcinomas expressing c-erbB-2 protein is derived from ductal in situ carcinomas of the comedo type.

Original languageEnglish (US)
Pages (from-to)117-121
Number of pages5
JournalPathobiology
Volume60
Issue number3
DOIs
StatePublished - Jan 1 1992
Externally publishedYes

Keywords

  • C-erbB-2
  • Comedo carcinoma in situ
  • HER-2
  • Mammary ductal adenocarcinoma
  • Oncogenes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cell Biology

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