TY - JOUR
T1 - Expression and function of a large non-coding RNA gene XIST in human cancer
AU - Weakley, Sarah M.
AU - Wang, Hao
AU - Yao, Qizhi
AU - Chen, Changyi
N1 - Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2011/8
Y1 - 2011/8
N2 - Background: X inactive-specific transcript (XIST) RNA is involved in X chromosome silencing in female cells and allows X chromosome equilibration with males. X inactive-specific transcript expression has been found to be dysregulated in a variety of human cancers when compared to normal cells; meanwhile, the inactivated X chromosome has been noted to be conspicuously absent in human cancer specimens, whereas X chromosome duplications are widely noted. The specific pathways whereby changes in X chromosome status and XIST expression occur in cancer remain incompletely described. Nevertheless, a role for XIST in BRCA1-mediated epigenetic activity has been proposed. Methods: Here we review the data regarding XIST expression and X chromosome status in a variety of female, male, and non-sex-related human cancers. Conclusions: It is not yet known whether X chromosome duplication, XIST dysregulation, and over-expression of X-linked genes represent important factors in tumorgenesis or are simply a consequence of overall epigenetic instability in these cancers.
AB - Background: X inactive-specific transcript (XIST) RNA is involved in X chromosome silencing in female cells and allows X chromosome equilibration with males. X inactive-specific transcript expression has been found to be dysregulated in a variety of human cancers when compared to normal cells; meanwhile, the inactivated X chromosome has been noted to be conspicuously absent in human cancer specimens, whereas X chromosome duplications are widely noted. The specific pathways whereby changes in X chromosome status and XIST expression occur in cancer remain incompletely described. Nevertheless, a role for XIST in BRCA1-mediated epigenetic activity has been proposed. Methods: Here we review the data regarding XIST expression and X chromosome status in a variety of female, male, and non-sex-related human cancers. Conclusions: It is not yet known whether X chromosome duplication, XIST dysregulation, and over-expression of X-linked genes represent important factors in tumorgenesis or are simply a consequence of overall epigenetic instability in these cancers.
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U2 - 10.1007/s00268-010-0951-0
DO - 10.1007/s00268-010-0951-0
M3 - Article
C2 - 21212949
AN - SCOPUS:80051574678
VL - 35
SP - 1751
EP - 1756
JO - World Journal of Surgery
JF - World Journal of Surgery
SN - 0364-2313
IS - 8
ER -