Expression and function of a large non-coding RNA gene XIST in human cancer

Sarah M. Weakley, Hao Wang, Qizhi Yao, Changyi Chen

Research output: Contribution to journalArticlepeer-review

109 Scopus citations


Background: X inactive-specific transcript (XIST) RNA is involved in X chromosome silencing in female cells and allows X chromosome equilibration with males. X inactive-specific transcript expression has been found to be dysregulated in a variety of human cancers when compared to normal cells; meanwhile, the inactivated X chromosome has been noted to be conspicuously absent in human cancer specimens, whereas X chromosome duplications are widely noted. The specific pathways whereby changes in X chromosome status and XIST expression occur in cancer remain incompletely described. Nevertheless, a role for XIST in BRCA1-mediated epigenetic activity has been proposed. Methods: Here we review the data regarding XIST expression and X chromosome status in a variety of female, male, and non-sex-related human cancers. Conclusions: It is not yet known whether X chromosome duplication, XIST dysregulation, and over-expression of X-linked genes represent important factors in tumorgenesis or are simply a consequence of overall epigenetic instability in these cancers.

Original languageEnglish (US)
Pages (from-to)1751-1756
Number of pages6
JournalWorld journal of surgery
Issue number8
StatePublished - Aug 2011
Externally publishedYes

ASJC Scopus subject areas

  • Surgery


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