Abstract
We discuss the Genetic Analysis Workshop 11 analyses of data from the Collaborative Study on the Genetics of Alcoholism from a methodological perspective, concentrating on approaches and issues relevant to linkage and association studies of complex human phenotypes. Genome screening by parametric linkage, nonparametric linkage, association, and combined linkage/association methods are discussed. Issues particular to complex disease include etiologic heterogeneity, multivariate phenotype modeling, and parent-of-origin effects. Other methodological topics discussed are new and enhanced methods, ascertainment, weighting of nonindependent sib pairs, and data cleaning and validation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | S1-S24 |
| Journal | Genetic epidemiology |
| Volume | 17 |
| Issue number | SUPPL. 1 |
| DOIs | |
| State | Published - 1999 |
| Externally published | Yes |
Keywords
- Ascertainment
- Association analysis
- Data validity
- Genome scan
- Heterogeneity
- Linkage analysis
- Parent of origin
- Statistical genetics
ASJC Scopus subject areas
- Epidemiology
- Genetics(clinical)