Exploring genetic analysis of complex traits through the paradigm of alcohol dependence

Summary of GAW11 contributions

Laura Almasy, Ingrid B. Borecki

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We discuss the Genetic Analysis Workshop 11 analyses of data from the Collaborative Study on the Genetics of Alcoholism from a methodological perspective, concentrating on approaches and issues relevant to linkage and association studies of complex human phenotypes. Genome screening by parametric linkage, nonparametric linkage, association, and combined linkage/association methods are discussed. Issues particular to complex disease include etiologic heterogeneity, multivariate phenotype modeling, and parent-of-origin effects. Other methodological topics discussed are new and enhanced methods, ascertainment, weighting of nonindependent sib pairs, and data cleaning and validation.

Original languageEnglish (US)
JournalGenetic Epidemiology
Volume17
Issue numberSUPPL. 1
StatePublished - 1999
Externally publishedYes

Fingerprint

Alcoholism
Phenotype
Genome
Education

Keywords

  • Ascertainment
  • Association analysis
  • Data validity
  • Genome scan
  • Heterogeneity
  • Linkage analysis
  • Parent of origin
  • Statistical genetics

ASJC Scopus subject areas

  • Genetics(clinical)
  • Epidemiology

Cite this

Exploring genetic analysis of complex traits through the paradigm of alcohol dependence : Summary of GAW11 contributions. / Almasy, Laura; Borecki, Ingrid B.

In: Genetic Epidemiology, Vol. 17, No. SUPPL. 1, 1999.

Research output: Contribution to journalArticle

@article{f411f280888b49daaea89385e79a67f9,
title = "Exploring genetic analysis of complex traits through the paradigm of alcohol dependence: Summary of GAW11 contributions",
abstract = "We discuss the Genetic Analysis Workshop 11 analyses of data from the Collaborative Study on the Genetics of Alcoholism from a methodological perspective, concentrating on approaches and issues relevant to linkage and association studies of complex human phenotypes. Genome screening by parametric linkage, nonparametric linkage, association, and combined linkage/association methods are discussed. Issues particular to complex disease include etiologic heterogeneity, multivariate phenotype modeling, and parent-of-origin effects. Other methodological topics discussed are new and enhanced methods, ascertainment, weighting of nonindependent sib pairs, and data cleaning and validation.",
keywords = "Ascertainment, Association analysis, Data validity, Genome scan, Heterogeneity, Linkage analysis, Parent of origin, Statistical genetics",
author = "Laura Almasy and Borecki, {Ingrid B.}",
year = "1999",
language = "English (US)",
volume = "17",
journal = "Genetic Epidemiology",
issn = "0741-0395",
publisher = "Wiley-Liss Inc.",
number = "SUPPL. 1",

}

TY - JOUR

T1 - Exploring genetic analysis of complex traits through the paradigm of alcohol dependence

T2 - Summary of GAW11 contributions

AU - Almasy, Laura

AU - Borecki, Ingrid B.

PY - 1999

Y1 - 1999

N2 - We discuss the Genetic Analysis Workshop 11 analyses of data from the Collaborative Study on the Genetics of Alcoholism from a methodological perspective, concentrating on approaches and issues relevant to linkage and association studies of complex human phenotypes. Genome screening by parametric linkage, nonparametric linkage, association, and combined linkage/association methods are discussed. Issues particular to complex disease include etiologic heterogeneity, multivariate phenotype modeling, and parent-of-origin effects. Other methodological topics discussed are new and enhanced methods, ascertainment, weighting of nonindependent sib pairs, and data cleaning and validation.

AB - We discuss the Genetic Analysis Workshop 11 analyses of data from the Collaborative Study on the Genetics of Alcoholism from a methodological perspective, concentrating on approaches and issues relevant to linkage and association studies of complex human phenotypes. Genome screening by parametric linkage, nonparametric linkage, association, and combined linkage/association methods are discussed. Issues particular to complex disease include etiologic heterogeneity, multivariate phenotype modeling, and parent-of-origin effects. Other methodological topics discussed are new and enhanced methods, ascertainment, weighting of nonindependent sib pairs, and data cleaning and validation.

KW - Ascertainment

KW - Association analysis

KW - Data validity

KW - Genome scan

KW - Heterogeneity

KW - Linkage analysis

KW - Parent of origin

KW - Statistical genetics

UR - http://www.scopus.com/inward/record.url?scp=0032736562&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032736562&partnerID=8YFLogxK

M3 - Article

VL - 17

JO - Genetic Epidemiology

JF - Genetic Epidemiology

SN - 0741-0395

IS - SUPPL. 1

ER -