Abstract
We discuss the Genetic Analysis Workshop 11 analyses of data from the Collaborative Study on the Genetics of Alcoholism from a methodological perspective, concentrating on approaches and issues relevant to linkage and association studies of complex human phenotypes. Genome screening by parametric linkage, nonparametric linkage, association, and combined linkage/association methods are discussed. Issues particular to complex disease include etiologic heterogeneity, multivariate phenotype modeling, and parent-of-origin effects. Other methodological topics discussed are new and enhanced methods, ascertainment, weighting of nonindependent sib pairs, and data cleaning and validation.
| Original language | English (US) |
|---|---|
| Journal | Genetic Epidemiology |
| Volume | 17 |
| Issue number | SUPPL. 1 |
| State | Published - 1999 |
| Externally published | Yes |
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Keywords
- Ascertainment
- Association analysis
- Data validity
- Genome scan
- Heterogeneity
- Linkage analysis
- Parent of origin
- Statistical genetics
ASJC Scopus subject areas
- Genetics(clinical)
- Epidemiology
Cite this
Exploring genetic analysis of complex traits through the paradigm of alcohol dependence : Summary of GAW11 contributions. / Almasy, Laura; Borecki, Ingrid B.
In: Genetic Epidemiology, Vol. 17, No. SUPPL. 1, 1999.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Exploring genetic analysis of complex traits through the paradigm of alcohol dependence
T2 - Summary of GAW11 contributions
AU - Almasy, Laura
AU - Borecki, Ingrid B.
PY - 1999
Y1 - 1999
N2 - We discuss the Genetic Analysis Workshop 11 analyses of data from the Collaborative Study on the Genetics of Alcoholism from a methodological perspective, concentrating on approaches and issues relevant to linkage and association studies of complex human phenotypes. Genome screening by parametric linkage, nonparametric linkage, association, and combined linkage/association methods are discussed. Issues particular to complex disease include etiologic heterogeneity, multivariate phenotype modeling, and parent-of-origin effects. Other methodological topics discussed are new and enhanced methods, ascertainment, weighting of nonindependent sib pairs, and data cleaning and validation.
AB - We discuss the Genetic Analysis Workshop 11 analyses of data from the Collaborative Study on the Genetics of Alcoholism from a methodological perspective, concentrating on approaches and issues relevant to linkage and association studies of complex human phenotypes. Genome screening by parametric linkage, nonparametric linkage, association, and combined linkage/association methods are discussed. Issues particular to complex disease include etiologic heterogeneity, multivariate phenotype modeling, and parent-of-origin effects. Other methodological topics discussed are new and enhanced methods, ascertainment, weighting of nonindependent sib pairs, and data cleaning and validation.
KW - Ascertainment
KW - Association analysis
KW - Data validity
KW - Genome scan
KW - Heterogeneity
KW - Linkage analysis
KW - Parent of origin
KW - Statistical genetics
UR - http://www.scopus.com/inward/record.url?scp=0032736562&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032736562&partnerID=8YFLogxK
M3 - Article
C2 - 10597406
AN - SCOPUS:0032736562
VL - 17
JO - Genetic Epidemiology
JF - Genetic Epidemiology
SN - 0741-0395
IS - SUPPL. 1
ER -