Exploring genetic analysis of complex traits through the paradigm of alcohol dependence: Summary of GAW11 contributions

Laura Almasy, Ingrid B. Borecki

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

We discuss the Genetic Analysis Workshop 11 analyses of data from the Collaborative Study on the Genetics of Alcoholism from a methodological perspective, concentrating on approaches and issues relevant to linkage and association studies of complex human phenotypes. Genome screening by parametric linkage, nonparametric linkage, association, and combined linkage/association methods are discussed. Issues particular to complex disease include etiologic heterogeneity, multivariate phenotype modeling, and parent-of-origin effects. Other methodological topics discussed are new and enhanced methods, ascertainment, weighting of nonindependent sib pairs, and data cleaning and validation.

Original languageEnglish (US)
Pages (from-to)S1-S24
JournalGenetic epidemiology
Volume17
Issue numberSUPPL. 1
DOIs
StatePublished - 1999
Externally publishedYes

Keywords

  • Ascertainment
  • Association analysis
  • Data validity
  • Genome scan
  • Heterogeneity
  • Linkage analysis
  • Parent of origin
  • Statistical genetics

ASJC Scopus subject areas

  • Epidemiology
  • Genetics(clinical)

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