Exploring genetic analysis of complex traits through the paradigm of alcohol dependence: Summary of GAW11 contributions

Laura Almasy, Ingrid B. Borecki

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    8 Scopus citations

    Abstract

    We discuss the Genetic Analysis Workshop 11 analyses of data from the Collaborative Study on the Genetics of Alcoholism from a methodological perspective, concentrating on approaches and issues relevant to linkage and association studies of complex human phenotypes. Genome screening by parametric linkage, nonparametric linkage, association, and combined linkage/association methods are discussed. Issues particular to complex disease include etiologic heterogeneity, multivariate phenotype modeling, and parent-of-origin effects. Other methodological topics discussed are new and enhanced methods, ascertainment, weighting of nonindependent sib pairs, and data cleaning and validation.

    Original languageEnglish (US)
    Pages (from-to)S1-S24
    JournalGenetic epidemiology
    Volume17
    Issue numberSUPPL. 1
    Publication statusPublished - Dec 10 1999

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    Keywords

    • Ascertainment
    • Association analysis
    • Data validity
    • Genome scan
    • Heterogeneity
    • Linkage analysis
    • Parent of origin
    • Statistical genetics

    ASJC Scopus subject areas

    • Epidemiology
    • Genetics(clinical)

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