Exploiting the Bioactive Properties of the Dentin-Pulp Complex in Regenerative Endodontics

Anthony J. Smith, Henry F. Duncan, Anibal Diogenes, Stephane Simon, Paul R. Cooper

Research output: Contribution to journalReview articlepeer-review

138 Scopus citations


Introduction The development of regenerative endodontic therapies offers exciting opportunities for future improvements in treatment outcomes. Methods Advances in our understanding of regenerative events at the molecular and cellular levels are helping to underpin development of these therapies, although the various strategies differ in the translational challenges they pose. The identification of a variety of bioactive molecules, including growth factors, cytokines, chemokines, and matrix molecules, sequestered within dentin and dental pulp provides the opportunity to present key signaling molecules promoting reparative and regenerative events after injury. Results and Conclusions The protection of the biological activity of these molecules by mineral in dentin before their release allows a continuing supply of these molecules, while avoiding the short half-life and the non-human origin of exogenous molecules. The ready release of these bioactive molecules by the various tissue preparation agents, medicaments, and materials commonly used in endodontics highlights the opportunities for translational regenerative strategies exploiting these molecules with little change to existing clinical practice.

Original languageEnglish (US)
Pages (from-to)47-56
Number of pages10
JournalJournal of endodontics
Issue number1
StatePublished - Jan 1 2016
Externally publishedYes


  • Bioactive molecules
  • cell signaling
  • dentin
  • pulp
  • regenerative endodontics

ASJC Scopus subject areas

  • General Dentistry


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