Experimentally-induced diabetes reduces nocturnal pineal melatonin content in the Syrian hamster

Thomas H. Champney; George C. Brainard; Bruce A. Richardson; Russel J. Reiter

doi:10.1016/0300-9629(83)90314-6

Experimentally-induced diabetes reduces nocturnal pineal melatonin content in the Syrian hamster

Thomas H. Champney, George C. Brainard, Bruce A. Richardson, Russel J. Reiter

Department of Cell Systems & Anatomy

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

1. 1. Male, Syrian hamsters were rendered diabetic by either alloxan (60mg/kg, i.v.) or streptozotocin (65 mg/kg, i.p.). 2. 2. Diabetic animals had reduced pineal melatonin contents during the night. Basal daytime values were not significantly altered. 3. 3. Diabetes may decrease melatonin synthesis by reducing the availability of glucose for metabolism or by decreasing the transport of tryptophan into pinealocytes for the synthesis of melatonin.

Original language	English (US)
Pages (from-to)	199-201
Number of pages	3
Journal	Comparative Biochemistry and Physiology -- Part A: Physiology
Volume	76
Issue number	1
DOIs	https://doi.org/10.1016/0300-9629(83)90314-6
State	Published - 1983

ASJC Scopus subject areas

Physiology

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title = "Experimentally-induced diabetes reduces nocturnal pineal melatonin content in the Syrian hamster",

abstract = "1. 1. Male, Syrian hamsters were rendered diabetic by either alloxan (60mg/kg, i.v.) or streptozotocin (65 mg/kg, i.p.). 2. 2. Diabetic animals had reduced pineal melatonin contents during the night. Basal daytime values were not significantly altered. 3. 3. Diabetes may decrease melatonin synthesis by reducing the availability of glucose for metabolism or by decreasing the transport of tryptophan into pinealocytes for the synthesis of melatonin.",

author = "Champney, {Thomas H.} and Brainard, {George C.} and Richardson, {Bruce A.} and Reiter, {Russel J.}",

note = "Funding Information: AcknoMlrdgemmrs-The authors wish to thank MS Meg Corrigan for her typing of the manuscript. The study was supported by NSF Grant No. PCM 8003441.",

year = "1983",

doi = "10.1016/0300-9629(83)90314-6",

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AU - Richardson, Bruce A.

AU - Reiter, Russel J.

N1 - Funding Information: AcknoMlrdgemmrs-The authors wish to thank MS Meg Corrigan for her typing of the manuscript. The study was supported by NSF Grant No. PCM 8003441.

PY - 1983

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N2 - 1. 1. Male, Syrian hamsters were rendered diabetic by either alloxan (60mg/kg, i.v.) or streptozotocin (65 mg/kg, i.p.). 2. 2. Diabetic animals had reduced pineal melatonin contents during the night. Basal daytime values were not significantly altered. 3. 3. Diabetes may decrease melatonin synthesis by reducing the availability of glucose for metabolism or by decreasing the transport of tryptophan into pinealocytes for the synthesis of melatonin.

AB - 1. 1. Male, Syrian hamsters were rendered diabetic by either alloxan (60mg/kg, i.v.) or streptozotocin (65 mg/kg, i.p.). 2. 2. Diabetic animals had reduced pineal melatonin contents during the night. Basal daytime values were not significantly altered. 3. 3. Diabetes may decrease melatonin synthesis by reducing the availability of glucose for metabolism or by decreasing the transport of tryptophan into pinealocytes for the synthesis of melatonin.

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Experimentally-induced diabetes reduces nocturnal pineal melatonin content in the Syrian hamster

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