TY - JOUR
T1 - Experimentally-induced diabetes reduces nocturnal pineal melatonin content in the Syrian hamster
AU - Champney, Thomas H.
AU - Brainard, George C.
AU - Richardson, Bruce A.
AU - Reiter, Russel J.
N1 - Funding Information:
AcknoMlrdgemmrs-The authors wish to thank MS Meg Corrigan for her typing of the manuscript. The study was supported by NSF Grant No. PCM 8003441.
PY - 1983
Y1 - 1983
N2 - 1. 1. Male, Syrian hamsters were rendered diabetic by either alloxan (60mg/kg, i.v.) or streptozotocin (65 mg/kg, i.p.). 2. 2. Diabetic animals had reduced pineal melatonin contents during the night. Basal daytime values were not significantly altered. 3. 3. Diabetes may decrease melatonin synthesis by reducing the availability of glucose for metabolism or by decreasing the transport of tryptophan into pinealocytes for the synthesis of melatonin.
AB - 1. 1. Male, Syrian hamsters were rendered diabetic by either alloxan (60mg/kg, i.v.) or streptozotocin (65 mg/kg, i.p.). 2. 2. Diabetic animals had reduced pineal melatonin contents during the night. Basal daytime values were not significantly altered. 3. 3. Diabetes may decrease melatonin synthesis by reducing the availability of glucose for metabolism or by decreasing the transport of tryptophan into pinealocytes for the synthesis of melatonin.
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U2 - 10.1016/0300-9629(83)90314-6
DO - 10.1016/0300-9629(83)90314-6
M3 - Article
C2 - 6138184
AN - SCOPUS:0020671366
SN - 0300-9629
VL - 76
SP - 199
EP - 201
JO - Comparative Biochemistry and Physiology -- Part A: Physiology
JF - Comparative Biochemistry and Physiology -- Part A: Physiology
IS - 1
ER -