Experimental therapy with azoles against Candida guilliermondii

Marta Sanchis, Francisco Javier Pastor, Javier Capilla, Deanna A. Sutton, Annette W. Fothergill, Josep Guarro

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

We evaluated the in vitro kffling activity of voriconazole (VRC) and posaconazole (PSC) against two clinical isolates of Candida guilliermondii. The two drugs showed fungistatic activity against both isolates and were effective in reducing kidney fungal burden in a neutropenic murine model of disseminated candidiasis in infected mice. PSC was significantly more effective than VRC against one of the strains. The serum levels of PSC and VRC were above the corresponding MICs for these isolates copyright

Original languageEnglish (US)
Pages (from-to)6255-6257
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume58
Issue number10
DOIs
StatePublished - Oct 1 2014

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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    Sanchis, M., Pastor, F. J., Capilla, J., Sutton, D. A., Fothergill, A. W., & Guarro, J. (2014). Experimental therapy with azoles against Candida guilliermondii. Antimicrobial agents and chemotherapy, 58(10), 6255-6257. https://doi.org/10.1128/AAC.03051-14