Experimental protein malnutrition decreases calcium binding protein in rat intestinal mucosa

W. A. Gleason, G. L. Lankford, D. C. Herbert

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Calcium-binding activity was measured in duodenal mucosal homogenates of rats 50 days after weaning onto a protein-deficient diet providing 3-4 g of protein per kilogram of body weight per day compared to control animals, who were fed an isocaloric diet providing 9-12 g of protein per kilogram of body weight per day. Calcium-binding activity was decreased (44% of control) further than can be explained by the decrease in intestinal mucosal weight (70% of control) or supernatant protein content (80% of control). The results suggest that the decrease in calcium-binding activity reflects decreased synthesis of the vitamin D-dependent calcium-binding protein (CaBP) as an adaptive response to the stunted growth associated with protein malnutrition.

Original languageEnglish (US)
Pages (from-to)1609-1613
Number of pages5
JournalJournal of Nutrition
Volume112
Issue number8
DOIs
StatePublished - 1982

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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