Experimental Pneumococcal Meningitis: III. Chemotactic Activity in Cerebrospinal Fluid

Charles M. Nolan; Robert A. Clark; Harry N. Beaty

doi:10.3181/00379727-150-38989

Experimental Pneumococcal Meningitis: III. Chemotactic Activity in Cerebrospinal Fluid

Charles M. Nolan, Robert A. Clark, Harry N. Beaty

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Chemotactic activity was assayed in CSF of rabbits with pneumococcal meningitis to further characterize the inflammatory response in this infection. CSF chemotactic activity was detected in increasing levels for 72 hr after infection. Activity was stable at 56° and was inactivated by agents which denature proteins. Gel filtration demonstrated two chemotactically active fractions in infected CSF with mol wts of approximately 3000 and 11,000. Bacterial products appear to account for a portion of the observed CSF chemotactic activity, but the role of host factors remains to be clarified.

Original language	English (US)
Pages (from-to)	134-136
Number of pages	3
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	150
Issue number	1
DOIs	https://doi.org/10.3181/00379727-150-38989
State	Published - Oct 1975
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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abstract = "Chemotactic activity was assayed in CSF of rabbits with pneumococcal meningitis to further characterize the inflammatory response in this infection. CSF chemotactic activity was detected in increasing levels for 72 hr after infection. Activity was stable at 56° and was inactivated by agents which denature proteins. Gel filtration demonstrated two chemotactically active fractions in infected CSF with mol wts of approximately 3000 and 11,000. Bacterial products appear to account for a portion of the observed CSF chemotactic activity, but the role of host factors remains to be clarified.",

author = "Nolan, {Charles M.} and Clark, {Robert A.} and Beaty, {Harry N.}",

note = "Funding Information: This work was supported by Grants CC00665 and AI03456 from the Center for Disease Control and the National Institute of Allergy and Infectious Disease. ",

year = "1975",

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doi = "10.3181/00379727-150-38989",

language = "English (US)",

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AU - Nolan, Charles M.

AU - Clark, Robert A.

AU - Beaty, Harry N.

N1 - Funding Information: This work was supported by Grants CC00665 and AI03456 from the Center for Disease Control and the National Institute of Allergy and Infectious Disease.

PY - 1975/10

Y1 - 1975/10

N2 - Chemotactic activity was assayed in CSF of rabbits with pneumococcal meningitis to further characterize the inflammatory response in this infection. CSF chemotactic activity was detected in increasing levels for 72 hr after infection. Activity was stable at 56° and was inactivated by agents which denature proteins. Gel filtration demonstrated two chemotactically active fractions in infected CSF with mol wts of approximately 3000 and 11,000. Bacterial products appear to account for a portion of the observed CSF chemotactic activity, but the role of host factors remains to be clarified.

AB - Chemotactic activity was assayed in CSF of rabbits with pneumococcal meningitis to further characterize the inflammatory response in this infection. CSF chemotactic activity was detected in increasing levels for 72 hr after infection. Activity was stable at 56° and was inactivated by agents which denature proteins. Gel filtration demonstrated two chemotactically active fractions in infected CSF with mol wts of approximately 3000 and 11,000. Bacterial products appear to account for a portion of the observed CSF chemotactic activity, but the role of host factors remains to be clarified.

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Experimental Pneumococcal Meningitis: III. Chemotactic Activity in Cerebrospinal Fluid

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