Experimental myocardial infarction in the closed-chest dog: A new technique

Christoph Zoll1kofer, Wilfrido Castaneda-Zuniga, Zeev Vlodaver, Joseph Rysavy, Antoinette S. Gomes, Kurt Amplatz

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


The reliable and safe production of myocardial infarction in closed-chest animals is of paramount research interest. To date, the injection of particulate matter and the introduction of occlusive solid plugs have been described. Because of the limited size of the catheter, only small branches could be occluded, which resulted in a high incidence of mortality. A new simple technique is described that allows occlusion of a major coronary artery at a preselected site. An Ivalon (polyvinyl alcohol) plug compressed around the tip of an introducing wire is advanced through a selectively placed catheter into the coronary artery. It is left in place for 5 minutes and assumes its original size upon contact with blood. Once the plug is re-expanded, the wire is withdrawn. The new technique was carried out successfully on nine dogs with no immediate fatality and myocardial infarction as demonstrated by cine ventriculography and histopathologic examination.

Original languageEnglish (US)
Pages (from-to)7-12
Number of pages6
JournalInvestigative Radiology
Issue number1
StatePublished - Jan 1 1981

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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