Experimental murine model of disseminated infection by Saksenaea vasiformis: Successful treatment with posaconazole

Valentina Salas, F. Javier Pastor, Enrique Calvo, Deanna Sutton, Dea García-Hermoso, Emilio Mayayo, Françoise Dromer, Anette Fothergill, Eduardo Alvarez, Josep Guarro

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

We have determined the in vitro activity of amphotericin B (AMB) and posaconazole (PSC) against Saksenaea vasiformis using broth microdilution and disk diffusion methods and determined the minimal fungicidal concentration (MFC). PSC was found to have the greatest in vitro activity in all cases and was the most efficacious in prolonging survival and reducing the fungal load in an immunocompetent murine model of disseminated infection caused by four strains of the fungus.

Original languageEnglish (US)
Pages (from-to)710-715
Number of pages6
JournalMedical mycology
Volume50
Issue number7
DOIs
StatePublished - Oct 1 2012

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Keywords

  • Murine model
  • Posaconazole
  • S. vasiformis

ASJC Scopus subject areas

  • Infectious Diseases

Cite this

Salas, V., Pastor, F. J., Calvo, E., Sutton, D., García-Hermoso, D., Mayayo, E., Dromer, F., Fothergill, A., Alvarez, E., & Guarro, J. (2012). Experimental murine model of disseminated infection by Saksenaea vasiformis: Successful treatment with posaconazole. Medical mycology, 50(7), 710-715. https://doi.org/10.3109/13693786.2012.673137