Experimental murine chromomycosis mimicking chronic progressive human disease

J. Ahrens, J. R. Graybill, A. Abishawl, F. O. Tio, M. G. Rinaldi

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

Congenitally athymic (nu/nu) mice, mice defective in NK cell and macrophage function (bg/bg), and normal BALB/c mice were inoculated sc with 105-6 conidia of Fonsecaea pedrosoi (FP). In immunologically intact and immunodeficient mice, a local infection developed approximately 2 weeks post-inoculation and enlarged over 1-2 weeks. In bg/bg and normal nu/+ mice, lesions resolved within 5-6 weeks. However, nu/nu mce continued to have enlarging sc lesions during > 4-6 months of observation. These evantually metastasized. Lesions contained few hyphal elements and massive numbers of sclerotic bodies. Five weeks after inoculation, 104-6 conidia forming units/gm of tissue were recovered from lesions. Delayed type hypersensitivity and serum antibody of FP antigens were demonstrated. Adoptive transfer of lymphocytes from nu/+ mice was followed in 2 months by the resolution of the lesions.

Original languageEnglish (US)
Pages (from-to)651-658
Number of pages8
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume40
Issue number6
DOIs
StatePublished - 1989
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology
  • Virology
  • Infectious Diseases

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