TY - JOUR
T1 - Experimental murine acremoniosis
T2 - An emerging opportunistic human infection
AU - Fernández-Silva, Fabiola
AU - Capilla, Javier
AU - Mayayo, Emilio
AU - Sutton, Deanna
AU - Guarro, Josep
PY - 2014
Y1 - 2014
N2 - Acremonium is an emerging fungal pathogen causing severe infections. We evaluated the virulence of three clinically relevant species within the genus, i.e., Acremonium kiliense (currently Sarocladium kiliense), Acremonium sclerotigenum-A. egyptiacum complex and Acremonium implicatum in a murine model of disseminated infection. Both immunocompetent and immunosuppresssed mice were infected with two inocula concentrations (2 × 106 and 2 × 108 conidia/animal) of two strains of each species. Tissue burden, mortality rate, histopathology and levels of (1→3)-β-D-glucan were used as virulence markers. None of the species of Acremonium tested was able to cause infection in immunocompetent mice. Conversely, severe infections were produced in immunocompromised mice, the spleen being the most affected organ. In general, the virulence of the Acremonium species tested was low, S. kiliense being the most virulent species.
AB - Acremonium is an emerging fungal pathogen causing severe infections. We evaluated the virulence of three clinically relevant species within the genus, i.e., Acremonium kiliense (currently Sarocladium kiliense), Acremonium sclerotigenum-A. egyptiacum complex and Acremonium implicatum in a murine model of disseminated infection. Both immunocompetent and immunosuppresssed mice were infected with two inocula concentrations (2 × 106 and 2 × 108 conidia/animal) of two strains of each species. Tissue burden, mortality rate, histopathology and levels of (1→3)-β-D-glucan were used as virulence markers. None of the species of Acremonium tested was able to cause infection in immunocompetent mice. Conversely, severe infections were produced in immunocompromised mice, the spleen being the most affected organ. In general, the virulence of the Acremonium species tested was low, S. kiliense being the most virulent species.
KW - Acremonium
KW - fungal infection
KW - immunosuppressed mice
KW - mycosis
KW - virulence
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U2 - 10.3109/13693786.2013.797610
DO - 10.3109/13693786.2013.797610
M3 - Article
C2 - 24577339
AN - SCOPUS:84887503818
VL - 52
SP - 29
EP - 35
JO - Medical Mycology
JF - Medical Mycology
SN - 1369-3786
IS - 1
ER -