Experimental murine acremoniosis: An emerging opportunistic human infection

Fabiola Fernández-Silva, Javier Capilla, Emilio Mayayo, Deanna Sutton, Josep Guarro

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Acremonium is an emerging fungal pathogen causing severe infections. We evaluated the virulence of three clinically relevant species within the genus, i.e., Acremonium kiliense (currently Sarocladium kiliense), Acremonium sclerotigenum-A. egyptiacum complex and Acremonium implicatum in a murine model of disseminated infection. Both immunocompetent and immunosuppresssed mice were infected with two inocula concentrations (2 × 106 and 2 × 108 conidia/animal) of two strains of each species. Tissue burden, mortality rate, histopathology and levels of (1→3)-β-D-glucan were used as virulence markers. None of the species of Acremonium tested was able to cause infection in immunocompetent mice. Conversely, severe infections were produced in immunocompromised mice, the spleen being the most affected organ. In general, the virulence of the Acremonium species tested was low, S. kiliense being the most virulent species.

Original languageEnglish (US)
Pages (from-to)29-35
Number of pages7
JournalMedical mycology
Volume52
Issue number1
DOIs
StatePublished - Jan 1 2014

Keywords

  • Acremonium
  • fungal infection
  • immunosuppressed mice
  • mycosis
  • virulence

ASJC Scopus subject areas

  • Infectious Diseases

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