Experimental histoplasmosis in the beige mouse

M. M. Patino, D. Williams, J. Ahrens, J. R. Graybill

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Mice carrying the beige mutation (bg/bg) on a C57Bl/6 background were challenged with Histoplasma capsulatum. bg/bg mice had higher mortality and higher lung tissue fungal counts in their lungs than either bg/+ or C57Bl/6 mice challenged with equal inocula. Immunologic studies showed that bg/bg mice developed normal delayed-type hypersensitivity (DHT) reactions to histoplasmin, but had deficient NK cell cytotoxic activity against YAC-1 target cells. Studies of macrophage killing of H. capsulatum in vitro showed that T lymphocytes of either bg/+ or bg/bg mice were able to activate fungal killing by bg/+ but not by bg/bg macrophages. These studies, while not excluding a role for the NK cell, suggest that macrophage dysfunction may be critical in the greater susceptibility of the bg/bg mouse and, by extension, that macrophage function is of major importance in host defense against H. capsulatum.

Original languageEnglish (US)
Pages (from-to)228-235
Number of pages8
JournalJournal of Leukocyte Biology
Issue number3
StatePublished - 1987
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Cell Biology


Dive into the research topics of 'Experimental histoplasmosis in the beige mouse'. Together they form a unique fingerprint.

Cite this