Experimental chemotherapy of histoplasmosis in nude mice

D. M. Williams, J. R. Graybill, D. J. Drutz

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Nude (nu/nu) mice were infected with Histoplasma capsulatum and treated with varying doses of 3 drug regimens: oral ambruticin, intraperitoneal amphotericin B, and amphotericin B plus oral rifampin. Therapy with amphotericin B alone was the most effective regimen. High-dose ambruticin (50 mg/kg of body weight every 8 hours) led to significantly prolonged survival compared to that of untreated control animals, but no long-term cures. Addition of rifampin produced no benefit and might actually have decreased the efficacy of amphotericin B; this combination may be deleterious in a setting of immunodeficiency.

Original languageEnglish (US)
Pages (from-to)837-842
Number of pages6
JournalAmerican Review of Respiratory Disease
Issue number4
StatePublished - 1979
Externally publishedYes

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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