Exotic mice for aging: Authors' reply

Richard A. Miller, David Burke, Steve Austad

Research output: Contribution to journalComment/debatepeer-review


The authors reply here to comments made by Drs. McClearn and Festing about the strengths and weaknesses of nonstandard mouse models in experimental gerontology, stressing once again the trade-off between internal and external validity. Although the use of genetically isogenic mice may, in some cases, minimize experimental costs by diminishing variance among individuals, reliance on a small number of inbred, long-domesticated stocks diminishes the external validity of a research program, i.e., the degree to which its conclusions give insights into questions of greater biological interest than the behavior of a single genotype.

Original languageEnglish (US)
Pages (from-to)245-246
Number of pages2
JournalNeurobiology of Aging
Issue number2
StatePublished - Jan 1 1999

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology


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