Abstract
The authors reply here to comments made by Drs. McClearn and Festing about the strengths and weaknesses of nonstandard mouse models in experimental gerontology, stressing once again the trade-off between internal and external validity. Although the use of genetically isogenic mice may, in some cases, minimize experimental costs by diminishing variance among individuals, reliance on a small number of inbred, long-domesticated stocks diminishes the external validity of a research program, i.e., the degree to which its conclusions give insights into questions of greater biological interest than the behavior of a single genotype.
Original language | English (US) |
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Pages (from-to) | 245-246 |
Number of pages | 2 |
Journal | Neurobiology of Aging |
Volume | 20 |
Issue number | 2 |
DOIs |
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State | Published - Jan 1 1999 |
ASJC Scopus subject areas
- Neuroscience(all)
- Aging
- Clinical Neurology
- Developmental Biology
- Geriatrics and Gerontology