Exotic mice for aging: Authors' reply

Richard A. Miller, David Burke, Steve Austad

Research output: Contribution to journalComment/debatepeer-review

Abstract

The authors reply here to comments made by Drs. McClearn and Festing about the strengths and weaknesses of nonstandard mouse models in experimental gerontology, stressing once again the trade-off between internal and external validity. Although the use of genetically isogenic mice may, in some cases, minimize experimental costs by diminishing variance among individuals, reliance on a small number of inbred, long-domesticated stocks diminishes the external validity of a research program, i.e., the degree to which its conclusions give insights into questions of greater biological interest than the behavior of a single genotype.

Original languageEnglish (US)
Pages (from-to)245-246
Number of pages2
JournalNeurobiology of Aging
Volume20
Issue number2
DOIs
StatePublished - Jan 1 1999

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

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