Exotic mice as models for aging research

Polemic and prospectus

Richard A. Miller, Steve Austad, David Burke, Clarence Chrisp, Robert Dysko, Andrzej Galecki, Anne Jackson, Vincent Monnier

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Most gerontological research using rodent models employs inbred strains, or F1 hybrids derived from them, rather than populations of genetically heterogeneous individuals. This study presents the argument that reliance on genetically homogeneous rodents, though sanctioned by tradition, may not be ideal for many sorts of investigations, and that use of heterogeneous mice and rats would allow researchers to reach robust conclusions that were less likely to reflect strain-specific idiosyncrasies. Segregating stocks, bred by backcross, F2 cross, or four-way cross procedures, would be an improvement over inbred and F1 stocks, providing inexpensive, arbitrarily large, and reproducible populations of genetically diverse test subjects. These stocks would not, however, recapture allelic variations that are likely to have been lost when wild-trapped mice and rats are selected inadvertently over dozens of generations for breeding success in laboratory conditions. Development of species pathogen free stocks from wild-trapped progenitors, particularly from populations selected for relevant evolutionary history and physiological characteristics, may be of great value for analysis of aging and late-life pathophysiology.

Original languageEnglish (US)
Pages (from-to)217-231
Number of pages15
JournalNeurobiology of Aging
Volume20
Issue number2
DOIs
StatePublished - 1999
Externally publishedYes

Fingerprint

Rodentia
Research
Population
Breeding
History
Research Personnel

Keywords

  • Aging
  • Animal models
  • Genetics
  • Gerontology
  • Inbreeding
  • Lifespan
  • Longevity
  • Mice
  • Rats
  • Selection

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • Psychology(all)

Cite this

Miller, R. A., Austad, S., Burke, D., Chrisp, C., Dysko, R., Galecki, A., ... Monnier, V. (1999). Exotic mice as models for aging research: Polemic and prospectus. Neurobiology of Aging, 20(2), 217-231. https://doi.org/10.1016/S0197-4580(99)00038-X

Exotic mice as models for aging research : Polemic and prospectus. / Miller, Richard A.; Austad, Steve; Burke, David; Chrisp, Clarence; Dysko, Robert; Galecki, Andrzej; Jackson, Anne; Monnier, Vincent.

In: Neurobiology of Aging, Vol. 20, No. 2, 1999, p. 217-231.

Research output: Contribution to journalArticle

Miller, RA, Austad, S, Burke, D, Chrisp, C, Dysko, R, Galecki, A, Jackson, A & Monnier, V 1999, 'Exotic mice as models for aging research: Polemic and prospectus', Neurobiology of Aging, vol. 20, no. 2, pp. 217-231. https://doi.org/10.1016/S0197-4580(99)00038-X
Miller RA, Austad S, Burke D, Chrisp C, Dysko R, Galecki A et al. Exotic mice as models for aging research: Polemic and prospectus. Neurobiology of Aging. 1999;20(2):217-231. https://doi.org/10.1016/S0197-4580(99)00038-X
Miller, Richard A. ; Austad, Steve ; Burke, David ; Chrisp, Clarence ; Dysko, Robert ; Galecki, Andrzej ; Jackson, Anne ; Monnier, Vincent. / Exotic mice as models for aging research : Polemic and prospectus. In: Neurobiology of Aging. 1999 ; Vol. 20, No. 2. pp. 217-231.
@article{6425ab9aa083466b93442207c2ad3176,
title = "Exotic mice as models for aging research: Polemic and prospectus",
abstract = "Most gerontological research using rodent models employs inbred strains, or F1 hybrids derived from them, rather than populations of genetically heterogeneous individuals. This study presents the argument that reliance on genetically homogeneous rodents, though sanctioned by tradition, may not be ideal for many sorts of investigations, and that use of heterogeneous mice and rats would allow researchers to reach robust conclusions that were less likely to reflect strain-specific idiosyncrasies. Segregating stocks, bred by backcross, F2 cross, or four-way cross procedures, would be an improvement over inbred and F1 stocks, providing inexpensive, arbitrarily large, and reproducible populations of genetically diverse test subjects. These stocks would not, however, recapture allelic variations that are likely to have been lost when wild-trapped mice and rats are selected inadvertently over dozens of generations for breeding success in laboratory conditions. Development of species pathogen free stocks from wild-trapped progenitors, particularly from populations selected for relevant evolutionary history and physiological characteristics, may be of great value for analysis of aging and late-life pathophysiology.",
keywords = "Aging, Animal models, Genetics, Gerontology, Inbreeding, Lifespan, Longevity, Mice, Rats, Selection",
author = "Miller, {Richard A.} and Steve Austad and David Burke and Clarence Chrisp and Robert Dysko and Andrzej Galecki and Anne Jackson and Vincent Monnier",
year = "1999",
doi = "10.1016/S0197-4580(99)00038-X",
language = "English (US)",
volume = "20",
pages = "217--231",
journal = "Neurobiology of Aging",
issn = "0197-4580",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - Exotic mice as models for aging research

T2 - Polemic and prospectus

AU - Miller, Richard A.

AU - Austad, Steve

AU - Burke, David

AU - Chrisp, Clarence

AU - Dysko, Robert

AU - Galecki, Andrzej

AU - Jackson, Anne

AU - Monnier, Vincent

PY - 1999

Y1 - 1999

N2 - Most gerontological research using rodent models employs inbred strains, or F1 hybrids derived from them, rather than populations of genetically heterogeneous individuals. This study presents the argument that reliance on genetically homogeneous rodents, though sanctioned by tradition, may not be ideal for many sorts of investigations, and that use of heterogeneous mice and rats would allow researchers to reach robust conclusions that were less likely to reflect strain-specific idiosyncrasies. Segregating stocks, bred by backcross, F2 cross, or four-way cross procedures, would be an improvement over inbred and F1 stocks, providing inexpensive, arbitrarily large, and reproducible populations of genetically diverse test subjects. These stocks would not, however, recapture allelic variations that are likely to have been lost when wild-trapped mice and rats are selected inadvertently over dozens of generations for breeding success in laboratory conditions. Development of species pathogen free stocks from wild-trapped progenitors, particularly from populations selected for relevant evolutionary history and physiological characteristics, may be of great value for analysis of aging and late-life pathophysiology.

AB - Most gerontological research using rodent models employs inbred strains, or F1 hybrids derived from them, rather than populations of genetically heterogeneous individuals. This study presents the argument that reliance on genetically homogeneous rodents, though sanctioned by tradition, may not be ideal for many sorts of investigations, and that use of heterogeneous mice and rats would allow researchers to reach robust conclusions that were less likely to reflect strain-specific idiosyncrasies. Segregating stocks, bred by backcross, F2 cross, or four-way cross procedures, would be an improvement over inbred and F1 stocks, providing inexpensive, arbitrarily large, and reproducible populations of genetically diverse test subjects. These stocks would not, however, recapture allelic variations that are likely to have been lost when wild-trapped mice and rats are selected inadvertently over dozens of generations for breeding success in laboratory conditions. Development of species pathogen free stocks from wild-trapped progenitors, particularly from populations selected for relevant evolutionary history and physiological characteristics, may be of great value for analysis of aging and late-life pathophysiology.

KW - Aging

KW - Animal models

KW - Genetics

KW - Gerontology

KW - Inbreeding

KW - Lifespan

KW - Longevity

KW - Mice

KW - Rats

KW - Selection

UR - http://www.scopus.com/inward/record.url?scp=0032877158&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032877158&partnerID=8YFLogxK

U2 - 10.1016/S0197-4580(99)00038-X

DO - 10.1016/S0197-4580(99)00038-X

M3 - Article

VL - 20

SP - 217

EP - 231

JO - Neurobiology of Aging

JF - Neurobiology of Aging

SN - 0197-4580

IS - 2

ER -