Exercise preserves muscle mass and force in a prostate cancer mouse model

Darpan I. Patel, Kira Abuchowski, Bilal Sheikh, Paul Rivas, Nicolas Musi, A. Pratap Kumar

Research output: Contribution to journalArticle

Abstract

The purpose of this study was to examine the effects of exercise in modulating biomarkers of sarcopenia in a treatment naïve transgenic adenocardinoma of the mouse prostate (TRAMP) model. Thirty TRAMP mice were randomized to either exercise (voluntary wheel running) or no-treatment control group for a period of 20 weeks. During necropsy, gastrocnemius muscles and prostate tumors were harvested and weighed. Gastrocnemius concentrations of myostatin, insulin-like growth factor (IGF)-1 and tumor necrosis factor (TNF)-α were quantified. Exercise mice had greater muscle mass than controls (p=0.04). Myostatin was significantly lower in the exercise group compared to controls (p=0.01). Exercise mice maintained forelimb grip force while control mice had a significaint decrease (p=0.01). No significant difference was observed in pre-post all limb grip strength. Further, forelimb and all limb grip strength was negatively associated with tumor mass (p<0.01).

Original languageEnglish (US)
Pages (from-to)328-333
Number of pages6
JournalEuropean Journal of Translational Myology
Volume29
Issue number4
DOIs
StatePublished - 2019

Keywords

  • Cachexia
  • Muscle strength
  • Physical activity
  • Sarcopenia

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Molecular Biology
  • Clinical Neurology
  • Cell Biology

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