Executive function in schizophrenia.

D. I. Velligan, C. C. Bow-Thomas

Research output: Contribution to journalReview articlepeer-review

100 Scopus citations


Many domains of executive function are impaired in patients with schizophrenia including forward planning, concept formation, initiation, self-monitoring, and the ability to direct attention and memory. These impairments are noticeable against a background of generalized cognitive deficits, and many affect 40% to 95% of individuals with this disorder. Specific executive deficits appear to be related to specific symptom clusters and are linked to structural and functional brain abnormalities. Executive impairment predicts multiple domains of functional outcome in schizophrenia patients. Atypical antipsychotic agents and cognitive rehabilitation may be promising new approaches for the treatment of cognitive and functional impairment in schizophrenia.

Original languageEnglish (US)
Pages (from-to)24-33
Number of pages10
JournalSeminars in clinical neuropsychiatry
Issue number1
StatePublished - Jan 1999

ASJC Scopus subject areas

  • General Neuroscience
  • Neuropsychology and Physiological Psychology


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