Abstract
Many domains of executive function are impaired in patients with schizophrenia including forward planning, concept formation, initiation, self-monitoring, and the ability to direct attention and memory. These impairments are noticeable against a background of generalized cognitive deficits, and many affect 40% to 95% of individuals with this disorder. Specific executive deficits appear to be related to specific symptom clusters and are linked to structural and functional brain abnormalities. Executive impairment predicts multiple domains of functional outcome in schizophrenia patients. Atypical antipsychotic agents and cognitive rehabilitation may be promising new approaches for the treatment of cognitive and functional impairment in schizophrenia.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 24-33 |
| Number of pages | 10 |
| Journal | Seminars in clinical neuropsychiatry |
| Volume | 4 |
| Issue number | 1 |
| State | Published - Jan 1999 |
ASJC Scopus subject areas
- General Neuroscience
- Neuropsychology and Physiological Psychology