Executive dysfunction and memory in older patients with major and minor depression (DOI:10.1016/j.acn.2006.05.011)

Virginia Elderkin-Thompson, Jim Mintz, Ebrahim Haroon, Helen Lavretsky, Anand Kumar

Research output: Contribution to journalComment/debatepeer-review

83 Scopus citations


Executive function, known to be impaired during late-life depression, is dependent on frontostriatal pathways. Memory is also frequently observed to be impaired among late-life depressed patients, so we assessed the possibility that executive function mediates the learning and recall deficit as a "downstream" effect of the frontostriatal compromise in executive function. A cross-sectional sample of minor and major depressed patients (N = 95) and nondepressed volunteers (N = 71), screened for other Axis I disorders, dementia, medical comorbidity and severity of depression, completed a neuropsychological battery that included the California Verbal Learning Test (CVLT) and other tests selected for convergent and divergent validity testing. Depressed patients differed from controls on learning the word list and on related and unrelated executive tasks. Executive function was a mediator for depressed patients verbal learning scores (z = -2.67, p = .01). A nonverbal executive score also mediated verbal learning (z = -2.18, p = .03) indicating convergent validity of executive dysfunction during verbal learning exercises. In conclusion, the verbal memory deficits typically attributed to late-life depression may result from impaired executive functioning during the learning phase of the recall task.

Original languageEnglish (US)
Pages (from-to)261-270
Number of pages10
JournalArchives of Clinical Neuropsychology
Issue number2
StatePublished - Feb 2007
Externally publishedYes


  • Cognition
  • Depression
  • Elderly
  • Executive function
  • Learning
  • Memory

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Clinical Psychology
  • Psychiatry and Mental health


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