Excretion of G14-Bilirubin in Newborn Guinea Pigs

Steven Schenker, Rudi Schmid

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Biliary excretion of injected unconjugated and conjugated C14-bilirubin was compared in one-day-old and in adult guinea pigs. In relation to adult animals, in the newborn elimination of unconjugated pigment was reduced by more than half and that of conjugated pigment, by one-third. This indicated that in addition to impaired conjugation, the liver of newborn animals exhibits an excretory defect, but the former represents the rate-limiting step in overall pigment metabolism.

Original languageEnglish (US)
Pages (from-to)446-448
Number of pages3
JournalProceedings of the Society for Experimental Biology and Medicine
Volume115
Issue number2
DOIs
StatePublished - Feb 1964
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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