TY - JOUR
T1 - Excretion of G14-Bilirubin in Newborn Guinea Pigs
AU - Schenker, Steven
AU - Schmid, Rudi
N1 - Funding Information:
Supported in part by U.S.P.H.S. grant.
PY - 1964/2
Y1 - 1964/2
N2 - Biliary excretion of injected unconjugated and conjugated C14-bilirubin was compared in one-day-old and in adult guinea pigs. In relation to adult animals, in the newborn elimination of unconjugated pigment was reduced by more than half and that of conjugated pigment, by one-third. This indicated that in addition to impaired conjugation, the liver of newborn animals exhibits an excretory defect, but the former represents the rate-limiting step in overall pigment metabolism.
AB - Biliary excretion of injected unconjugated and conjugated C14-bilirubin was compared in one-day-old and in adult guinea pigs. In relation to adult animals, in the newborn elimination of unconjugated pigment was reduced by more than half and that of conjugated pigment, by one-third. This indicated that in addition to impaired conjugation, the liver of newborn animals exhibits an excretory defect, but the former represents the rate-limiting step in overall pigment metabolism.
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U2 - 10.3181/00379727-115-28937
DO - 10.3181/00379727-115-28937
M3 - Article
C2 - 14121634
AN - SCOPUS:9744268467
VL - 115
SP - 446
EP - 448
JO - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)
JF - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)
SN - 1535-3702
IS - 2
ER -