Excretion and toxicity of gold-iron nanoparticles

James T. Jenkins, David L. Halaney, Konstantin V. Sokolov, Li L. Ma, Heather J. Shipley, Smridhi Mahajan, Christopher L. Louden, Reto Asmis, Thomas E. Milner, Keith P. Johnston, Marc D Feldman

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Though gold nanoparticles have been considered bio-inert, recent studies have questioned their safety. To reduce the potential for toxicity, we developed a nanoclustering of gold and iron oxide as a nanoparticle (nanorose) which biodegrades into subunits to facilitate rapid excretion. In this present study, we demonstrate acid and macrophage lysosomal degradation of nanorose via loss of the near-infrared optical shift, and clearance of the nanorose in vivo following i.v. administration in C57BL/6 mice by showing gold concentration is significantly reduced in 11 murine tissues in as little as 31. days (P < 0.01). Hematology and chemistry show no toxicity of nanorose injected mice up to 14 days after administration. We conclude that the clustering design of nanorose does enhance the excretion of these nanoparticles, and that this could be a viable strategy to limit the potential toxicity of gold nanoparticles for clinical applications. From the Clinical Editor: The potential toxicity of nanomaterials is a critically important limiting factor in their more widespread clinical application. Gold nanoparticles have been classically considered bio-inert, but recent studies have questioned their safety. The authors of this study have developed a clustering gold and iron oxide nanoparticle (nanorose), which biodegrades into subunits to facilitate rapid excretion, resulting in reduced toxicity.

Original languageEnglish (US)
Pages (from-to)356-365
Number of pages10
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Volume9
Issue number3
DOIs
StatePublished - Apr 2013

Fingerprint

Gold
Nanoparticles
Toxicity
Iron
Iron oxides
Cluster Analysis
Safety
Nanostructures
Macrophages
Hematology
Inbred C57BL Mouse
Nanostructured materials
Tissue
Infrared radiation
Degradation
Acids
ferric oxide

Keywords

  • Biodegradation
  • Excretion
  • Gold nanoparticles
  • Iron oxide
  • Toxicity

ASJC Scopus subject areas

  • Molecular Medicine
  • Bioengineering
  • Biomedical Engineering
  • Materials Science(all)
  • Medicine (miscellaneous)
  • Pharmaceutical Science

Cite this

Jenkins, J. T., Halaney, D. L., Sokolov, K. V., Ma, L. L., Shipley, H. J., Mahajan, S., ... Feldman, M. D. (2013). Excretion and toxicity of gold-iron nanoparticles. Nanomedicine: Nanotechnology, Biology, and Medicine, 9(3), 356-365. https://doi.org/10.1016/j.nano.2012.08.007

Excretion and toxicity of gold-iron nanoparticles. / Jenkins, James T.; Halaney, David L.; Sokolov, Konstantin V.; Ma, Li L.; Shipley, Heather J.; Mahajan, Smridhi; Louden, Christopher L.; Asmis, Reto; Milner, Thomas E.; Johnston, Keith P.; Feldman, Marc D.

In: Nanomedicine: Nanotechnology, Biology, and Medicine, Vol. 9, No. 3, 04.2013, p. 356-365.

Research output: Contribution to journalArticle

Jenkins, JT, Halaney, DL, Sokolov, KV, Ma, LL, Shipley, HJ, Mahajan, S, Louden, CL, Asmis, R, Milner, TE, Johnston, KP & Feldman, MD 2013, 'Excretion and toxicity of gold-iron nanoparticles', Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 9, no. 3, pp. 356-365. https://doi.org/10.1016/j.nano.2012.08.007
Jenkins JT, Halaney DL, Sokolov KV, Ma LL, Shipley HJ, Mahajan S et al. Excretion and toxicity of gold-iron nanoparticles. Nanomedicine: Nanotechnology, Biology, and Medicine. 2013 Apr;9(3):356-365. https://doi.org/10.1016/j.nano.2012.08.007
Jenkins, James T. ; Halaney, David L. ; Sokolov, Konstantin V. ; Ma, Li L. ; Shipley, Heather J. ; Mahajan, Smridhi ; Louden, Christopher L. ; Asmis, Reto ; Milner, Thomas E. ; Johnston, Keith P. ; Feldman, Marc D. / Excretion and toxicity of gold-iron nanoparticles. In: Nanomedicine: Nanotechnology, Biology, and Medicine. 2013 ; Vol. 9, No. 3. pp. 356-365.
@article{701ca2a721c44aaeb83170bd36fb97d9,
title = "Excretion and toxicity of gold-iron nanoparticles",
abstract = "Though gold nanoparticles have been considered bio-inert, recent studies have questioned their safety. To reduce the potential for toxicity, we developed a nanoclustering of gold and iron oxide as a nanoparticle (nanorose) which biodegrades into subunits to facilitate rapid excretion. In this present study, we demonstrate acid and macrophage lysosomal degradation of nanorose via loss of the near-infrared optical shift, and clearance of the nanorose in vivo following i.v. administration in C57BL/6 mice by showing gold concentration is significantly reduced in 11 murine tissues in as little as 31. days (P < 0.01). Hematology and chemistry show no toxicity of nanorose injected mice up to 14 days after administration. We conclude that the clustering design of nanorose does enhance the excretion of these nanoparticles, and that this could be a viable strategy to limit the potential toxicity of gold nanoparticles for clinical applications. From the Clinical Editor: The potential toxicity of nanomaterials is a critically important limiting factor in their more widespread clinical application. Gold nanoparticles have been classically considered bio-inert, but recent studies have questioned their safety. The authors of this study have developed a clustering gold and iron oxide nanoparticle (nanorose), which biodegrades into subunits to facilitate rapid excretion, resulting in reduced toxicity.",
keywords = "Biodegradation, Excretion, Gold nanoparticles, Iron oxide, Toxicity",
author = "Jenkins, {James T.} and Halaney, {David L.} and Sokolov, {Konstantin V.} and Ma, {Li L.} and Shipley, {Heather J.} and Smridhi Mahajan and Louden, {Christopher L.} and Reto Asmis and Milner, {Thomas E.} and Johnston, {Keith P.} and Feldman, {Marc D}",
year = "2013",
month = "4",
doi = "10.1016/j.nano.2012.08.007",
language = "English (US)",
volume = "9",
pages = "356--365",
journal = "Nanomedicine: Nanotechnology, Biology, and Medicine",
issn = "1549-9634",
publisher = "Elsevier Inc.",
number = "3",

}

TY - JOUR

T1 - Excretion and toxicity of gold-iron nanoparticles

AU - Jenkins, James T.

AU - Halaney, David L.

AU - Sokolov, Konstantin V.

AU - Ma, Li L.

AU - Shipley, Heather J.

AU - Mahajan, Smridhi

AU - Louden, Christopher L.

AU - Asmis, Reto

AU - Milner, Thomas E.

AU - Johnston, Keith P.

AU - Feldman, Marc D

PY - 2013/4

Y1 - 2013/4

N2 - Though gold nanoparticles have been considered bio-inert, recent studies have questioned their safety. To reduce the potential for toxicity, we developed a nanoclustering of gold and iron oxide as a nanoparticle (nanorose) which biodegrades into subunits to facilitate rapid excretion. In this present study, we demonstrate acid and macrophage lysosomal degradation of nanorose via loss of the near-infrared optical shift, and clearance of the nanorose in vivo following i.v. administration in C57BL/6 mice by showing gold concentration is significantly reduced in 11 murine tissues in as little as 31. days (P < 0.01). Hematology and chemistry show no toxicity of nanorose injected mice up to 14 days after administration. We conclude that the clustering design of nanorose does enhance the excretion of these nanoparticles, and that this could be a viable strategy to limit the potential toxicity of gold nanoparticles for clinical applications. From the Clinical Editor: The potential toxicity of nanomaterials is a critically important limiting factor in their more widespread clinical application. Gold nanoparticles have been classically considered bio-inert, but recent studies have questioned their safety. The authors of this study have developed a clustering gold and iron oxide nanoparticle (nanorose), which biodegrades into subunits to facilitate rapid excretion, resulting in reduced toxicity.

AB - Though gold nanoparticles have been considered bio-inert, recent studies have questioned their safety. To reduce the potential for toxicity, we developed a nanoclustering of gold and iron oxide as a nanoparticle (nanorose) which biodegrades into subunits to facilitate rapid excretion. In this present study, we demonstrate acid and macrophage lysosomal degradation of nanorose via loss of the near-infrared optical shift, and clearance of the nanorose in vivo following i.v. administration in C57BL/6 mice by showing gold concentration is significantly reduced in 11 murine tissues in as little as 31. days (P < 0.01). Hematology and chemistry show no toxicity of nanorose injected mice up to 14 days after administration. We conclude that the clustering design of nanorose does enhance the excretion of these nanoparticles, and that this could be a viable strategy to limit the potential toxicity of gold nanoparticles for clinical applications. From the Clinical Editor: The potential toxicity of nanomaterials is a critically important limiting factor in their more widespread clinical application. Gold nanoparticles have been classically considered bio-inert, but recent studies have questioned their safety. The authors of this study have developed a clustering gold and iron oxide nanoparticle (nanorose), which biodegrades into subunits to facilitate rapid excretion, resulting in reduced toxicity.

KW - Biodegradation

KW - Excretion

KW - Gold nanoparticles

KW - Iron oxide

KW - Toxicity

UR - http://www.scopus.com/inward/record.url?scp=84875503367&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84875503367&partnerID=8YFLogxK

U2 - 10.1016/j.nano.2012.08.007

DO - 10.1016/j.nano.2012.08.007

M3 - Article

C2 - 22960192

AN - SCOPUS:84875503367

VL - 9

SP - 356

EP - 365

JO - Nanomedicine: Nanotechnology, Biology, and Medicine

JF - Nanomedicine: Nanotechnology, Biology, and Medicine

SN - 1549-9634

IS - 3

ER -