Excretion and toxicity of gold-iron nanoparticles

James T. Jenkins, David L. Halaney, Konstantin V. Sokolov, Li L. Ma, Heather J. Shipley, Smridhi Mahajan, Christopher L. Louden, Reto Asmis, Thomas E. Milner, Keith P. Johnston, Marc D. Feldman

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

Though gold nanoparticles have been considered bio-inert, recent studies have questioned their safety. To reduce the potential for toxicity, we developed a nanoclustering of gold and iron oxide as a nanoparticle (nanorose) which biodegrades into subunits to facilitate rapid excretion. In this present study, we demonstrate acid and macrophage lysosomal degradation of nanorose via loss of the near-infrared optical shift, and clearance of the nanorose in vivo following i.v. administration in C57BL/6 mice by showing gold concentration is significantly reduced in 11 murine tissues in as little as 31. days (P < 0.01). Hematology and chemistry show no toxicity of nanorose injected mice up to 14 days after administration. We conclude that the clustering design of nanorose does enhance the excretion of these nanoparticles, and that this could be a viable strategy to limit the potential toxicity of gold nanoparticles for clinical applications. From the Clinical Editor: The potential toxicity of nanomaterials is a critically important limiting factor in their more widespread clinical application. Gold nanoparticles have been classically considered bio-inert, but recent studies have questioned their safety. The authors of this study have developed a clustering gold and iron oxide nanoparticle (nanorose), which biodegrades into subunits to facilitate rapid excretion, resulting in reduced toxicity.

Original languageEnglish (US)
Pages (from-to)356-365
Number of pages10
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Volume9
Issue number3
DOIs
StatePublished - Apr 1 2013

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Keywords

  • Biodegradation
  • Excretion
  • Gold nanoparticles
  • Iron oxide
  • Toxicity

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Molecular Medicine
  • Biomedical Engineering
  • Materials Science(all)
  • Pharmaceutical Science

Cite this

Jenkins, J. T., Halaney, D. L., Sokolov, K. V., Ma, L. L., Shipley, H. J., Mahajan, S., Louden, C. L., Asmis, R., Milner, T. E., Johnston, K. P., & Feldman, M. D. (2013). Excretion and toxicity of gold-iron nanoparticles. Nanomedicine: Nanotechnology, Biology, and Medicine, 9(3), 356-365. https://doi.org/10.1016/j.nano.2012.08.007