Excess androgenicity only partially explains the relationship between obesity and bone density in premenopausal women

S. M. Haffner, R. L. Bauer

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

Obese subjects have increased bone density relative to non-obese subjects yet this relationship is not fully understood. We examined whether alterations in sex hormones or binding proteins might explain the effect of obesity on osteoporosis in 83 premenopausal women from the San Antonio Heart Study, a population-based study of diabetes. We measured total testosterone, oestradiol, oestrone, sex hormone binding globulin (SHBG), and serum dehydroepiandrosterone sulphate (DHEA-SO4). Bone density was assessed by a Hologic dual photon absorptometer. Lumbar spine and femoral neck density were positively correlated with body mass index (BMI). In addition, femoral neck density was positively correlated with DHEA-SO4. BMI was negatively correlated with SHBG. After adjustment for sex hormones by multiple linear regression a positive association between bone density and obesity still exists suggesting that the association between obesity and bone density is at least partially independent of sex steroids in premenopausal women.

Original languageEnglish (US)
Pages (from-to)869-874
Number of pages6
JournalInternational Journal of Obesity
Volume16
Issue number11
StatePublished - 1992
Externally publishedYes

Keywords

  • Bone density
  • Osteoporosis
  • Sex hormones

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

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