Exceptional cellular resistance to oxidative damage in long-lived birds requires active gene expression

C. E. Ogburn, K. Carlberg, M. A. Ottinger, D. J. Holmes, G. M. Martin, S. N. Austad

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

Previous studies indicated that renal tubular epithelial cells from some long-lived avian species exhibit robust and/or unique protective mechanisms against oxidative stress relative to murine cells. Here we extend these studies to investigate the response of primary embryonic fibroblast-like cells to oxidative challenge in long- and short-lived avian species (budgerigar, Melopsittacus undulatus, longevity up to 20 years, vs Japanese quail, Coturnix coturnix japonica, longevity up to 5 years) and short- and long-lived mammalian species (house mouse, Mus musculus, longevity up to 4 years vs humans, Homo sapiens, longevity up to 122 years). Under the conditions of our assay, the oxidative-damage resistance phenotype appears to be associated with exceptional longevity in avian species, but not in mammals. Furthermore, the extreme oxidative damage resistance phenotype observed in a long-lived bird requires active gene transcription and translation, suggesting that specific gene products may have evolved in long-lived birds to facilitate resistance to oxidative stress.

Original languageEnglish (US)
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume56
Issue number11
StatePublished - 2001
Externally publishedYes

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Birds
Coturnix
Gene Expression
Melopsittacus
Oxidative Stress
Phenotype
Genes
Mammals
Fibroblasts
Epithelial Cells
Kidney

ASJC Scopus subject areas

  • Aging

Cite this

Exceptional cellular resistance to oxidative damage in long-lived birds requires active gene expression. / Ogburn, C. E.; Carlberg, K.; Ottinger, M. A.; Holmes, D. J.; Martin, G. M.; Austad, S. N.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 56, No. 11, 2001.

Research output: Contribution to journalArticle

Ogburn, C. E. ; Carlberg, K. ; Ottinger, M. A. ; Holmes, D. J. ; Martin, G. M. ; Austad, S. N. / Exceptional cellular resistance to oxidative damage in long-lived birds requires active gene expression. In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 2001 ; Vol. 56, No. 11.
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