Excavating relics of DNA methylation changes during the development of neoplasia

Shu Huei Hsiao, Tim H.M. Huang, Yu Wei Leu

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations


Epigenetic events like DNA methylation are known to regulate gene expression, and dysregulation of these events is associated with neoplastic proliferation. Here, we provide a step-by-step review of the approach that has gradually developed to identify critical DNA methylation during neoplasia. DNA methylation has first been tightly linked to the regulation of gene expression and functions. Next, the clinical importance of such DNA methylation has been probed by inducing loss of the maintenance of normal DNA methylation, which has been found to trigger onset of disease. Methylation changes can be signal-specific and lineage-specific, providing a record what cells have encountered and what they have become. Comparison of methylation associated with normal cellular differentiation and abnormal cell fate changes is expected to uncover critical methylation changes. We also propose a specific scheme that can be used to excavate critical DNA methylation associated with cell evolution.

Original languageEnglish (US)
Pages (from-to)198-208
Number of pages11
JournalSeminars in Cancer Biology
Issue number3
StatePublished - Jun 2009
Externally publishedYes


  • Cancer and cell signaling
  • DNA methylation
  • Epigenetics

ASJC Scopus subject areas

  • Cancer Research


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