Examination of fluconazole-induced alopecia in an animal model and human cohort

George R. Thompson; Charles R. Krois; Verena K. Affolter; Angela D. Everett; E. Katarina Varjonen; Victoria R. Sharon; Anil Singapuri; Michael Dennis; Ian McHardy; Hong Sik Yoo; Dawn M. Fedor; Nathan P. Wiederhold; Phylicia A. Aaron; Angie Gelli; Joseph L. Napoli; Stephen D. White

doi:10.1128/AAC.01384-18

Examination of fluconazole-induced alopecia in an animal model and human cohort

George R. Thompson, Charles R. Krois, Verena K. Affolter, Angela D. Everett, E. Katarina Varjonen, Victoria R. Sharon, Anil Singapuri, Michael Dennis, Ian McHardy, Hong Sik Yoo, Dawn M. Fedor, Nathan P. Wiederhold, Phylicia A. Aaron, Angie Gelli, Joseph L. Napoli, Stephen D. White

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Fluconazole-induced alopecia is a significant problem for patients receiving long-term therapy. We evaluated the hair cycle changes of fluconazole in a rat model and investigated potential molecular mechanisms. Plasma and tissue levels of retinoic acid were not found to be causal. Human patients with alopecia attributed to fluconazole also underwent detailed assessment and in both our murine model and human cohort fluconazole induced telogen effluvium. Future work further examining the mechanism of fluconazole-induced alopecia should be undertaken.

Original language	English (US)
Article number	e01384-18
Journal	Antimicrobial agents and chemotherapy
Volume	63
Issue number	2
DOIs	https://doi.org/10.1128/AAC.01384-18
State	Published - Feb 2019

Keywords

Alopecia
Antifungal
Fluconazole
Side effect

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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Thompson, G. R., Krois, C. R., Affolter, V. K., Everett, A. D., Katarina Varjonen, E., Sharon, V. R., Singapuri, A., Dennis, M., McHardy, I., Yoo, H. S., Fedor, D. M., Wiederhold, N. P., Aaron, P. A., Gelli, A., Napoli, J. L., & White, S. D. (2019). Examination of fluconazole-induced alopecia in an animal model and human cohort. Antimicrobial agents and chemotherapy, 63(2), Article e01384-18. https://doi.org/10.1128/AAC.01384-18

Thompson, GR, Krois, CR, Affolter, VK, Everett, AD, Katarina Varjonen, E, Sharon, VR, Singapuri, A, Dennis, M, McHardy, I, Yoo, HS, Fedor, DM, Wiederhold, NP, Aaron, PA, Gelli, A, Napoli, JL & White, SD 2019, 'Examination of fluconazole-induced alopecia in an animal model and human cohort', Antimicrobial agents and chemotherapy, vol. 63, no. 2, e01384-18. https://doi.org/10.1128/AAC.01384-18

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abstract = "Fluconazole-induced alopecia is a significant problem for patients receiving long-term therapy. We evaluated the hair cycle changes of fluconazole in a rat model and investigated potential molecular mechanisms. Plasma and tissue levels of retinoic acid were not found to be causal. Human patients with alopecia attributed to fluconazole also underwent detailed assessment and in both our murine model and human cohort fluconazole induced telogen effluvium. Future work further examining the mechanism of fluconazole-induced alopecia should be undertaken.",

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AU - Katarina Varjonen, E.

AU - Sharon, Victoria R.

AU - Singapuri, Anil

AU - Dennis, Michael

AU - McHardy, Ian

AU - Yoo, Hong Sik

AU - Fedor, Dawn M.

AU - Wiederhold, Nathan P.

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AU - Napoli, Joseph L.

AU - White, Stephen D.

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AB - Fluconazole-induced alopecia is a significant problem for patients receiving long-term therapy. We evaluated the hair cycle changes of fluconazole in a rat model and investigated potential molecular mechanisms. Plasma and tissue levels of retinoic acid were not found to be causal. Human patients with alopecia attributed to fluconazole also underwent detailed assessment and in both our murine model and human cohort fluconazole induced telogen effluvium. Future work further examining the mechanism of fluconazole-induced alopecia should be undertaken.

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Examination of fluconazole-induced alopecia in an animal model and human cohort

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Keywords

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