Examination of association with candidate genes for diabetic nephropathy in a mexican american population

Sulgi Kim, Hanna E. Abboud, Madeleine V. Pahl, John Tayek, Susan Snyder, James Tamkin, Harry Alcorn, Eli Ipp, Cynthia C. Nast, Robert C. Elston, Sudha K. Iyengar, Sharon G. Adler

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Background and objectives: Diabetic nephropathy (DN) is a multifactorial complication characterized by persistent proteinuria in susceptible individuals with type 1 and type 2 diabetes. Disease burden in people of Mexican-American descent is particularly high, but there are only a few studies that characterize genes for DN in this ethnic group. Two genes, carnosine dipeptidase 1 (CNDP1) and engulfment and cell motility 1 (ELMO1) previously showed association with DN in other ethnic groups. CNDP1 and ELMO1 were examined along with eight other genes that are less well characterized for DN in a new study of Mexican-Americans. Design, setting, participants, & measurements: The target sample was patients of Mexican-American ancestry collected from three centers: 455 patients with DN and 437 controls with long-term diabetes but no incident nephropathy. Forty-two, 227, and 401 single nucleotide polymorphisms (SNPs) in CNDP1, ELMO1, and the other eight genes, respectively, were examined. Results: No region in CNDP1 or ELMO1 showed significant P values. Of the other eight candidate genes, an association of DN with a SNP pair, rs2146098 and rs6659783, was found in hemicentin 1 (HMCN1) (unadjusted P = 6.1 × 10-5). Association with a rare haplotype in this region was subsequently identified. Conclusions: The associations in CNDP1 or ELMO1 were not replicable; however, an association of DN with HMCN1 was found. Additional work at this and other loci will enable refinement of the genetic hypotheses regarding DN in the Mexican-American population to find therapies for this debilitating disease.

Original languageEnglish (US)
Pages (from-to)1072-1078
Number of pages7
JournalClinical Journal of the American Society of Nephrology
Volume5
Issue number6
DOIs
StatePublished - Jun 1 2010

ASJC Scopus subject areas

  • Epidemiology
  • Critical Care and Intensive Care Medicine
  • Nephrology
  • Transplantation

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