Evolutionary relationships among the malate dehydrogenases

Lee McAlister-Henn

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


The three-dimensional structures and elements essential for catalysis are conserved between mitochondrial and cytoplasmic forms of malate dehydrogenase in eukaryotic cells even though these isozymes are only marginally related at the level of primary structure. The high degree of similarity between amino acid sequences of eukaryotic mitochondrial and Escherichia coli malate dehydrogenases may thus reflect evolutionary pressure to retain structural elements for functions other than catalysis.

Original languageEnglish (US)
Pages (from-to)178-181
Number of pages4
JournalTrends in Biochemical Sciences
Issue number5
StatePublished - May 1988

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology


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