Evolutionary conservation between budding yeast and human kinetochores

Katsumi Kitagawa, Philip Hieter

Research output: Contribution to journalReview article

85 Scopus citations

Abstract

Accurate chromosome segregation during mitosis requires the correct assembly of kinetochores - complexes of centromeric DNA and proteins that link chromosomes to spindle microtubules. Studies on the kinetochore of the budding yeast Saccharomyces cerevisiae have revealed functionally novel components of the kinetochore and its regulatory complexes, some of which are highly conserved in humans.

Original languageEnglish (US)
Pages (from-to)678-687
Number of pages10
JournalNature Reviews Molecular Cell Biology
Volume2
Issue number9
DOIs
StatePublished - Sep 1 2001
Externally publishedYes

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ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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