Evidence that brain angiotensin II is involved in both thirst and sodium appetite in baboons

J. R. Blair-West, K. D. Carey, D. A. Denton, R. S. Weisinger, R. E. Shade

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    18 Scopus citations


    The roles of ANG II in the brain mechanisms subserving thirst and Na appetite in baboons were investigated by chronic intracerebroventricular infusions of ANG II and AT1-receptor antagonists using subcutaneous miniosmotic pumps and by oral administration of captopril. ANG II at 3 or 5 μg/h for 7 days increased water intake from 2,455 ± 107 to 7,052 ± 562 ml/day by day 6 and 300 mM NaCl intake from 8.3 ± 1.1 to 275 ± 87 mmol/day by day 5. Concurrent intracerebroventricular losartan (300 μg/h) did not substantially reduce these responses, but they were abolished by intracerebroventricular ZD-7155 (50 μg/h). The increase of 300 mM NaCl intake when it was offered after intramuscular injection of furosemide, 2 mg · kg-1 · day-1 for 3 days, was unaltered by intracerebroventricular losartan (300 μg/h) but was reduced by intracerebroventricular ZD-7155 (50 μg/h) infused throughout Na depletion/repletion; oral captopril (1 g, 3 and 18 h before access to 300 mM NaCl) also reduced NaCl intake. Restriction of water intake to 25% of daily intake for 3 days caused a high intake of water on day 4, and this was reduced by intracerebroventricular losartan (300 μg/h) infused throughout the period of water restriction/rehydration. These novel results in a primate species suggest that brain ANG II is involved in both thirst and Na appetite, acting via AT1 receptors.

    Original languageEnglish (US)
    Pages (from-to)R1639-R1646
    JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
    Issue number5 44-5
    StatePublished - Nov 1998


    • Angiotensin receptors
    • Captopril
    • Losartan
    • Nonhuman primate
    • Sodium appetite
    • ZD- 7155

    ASJC Scopus subject areas

    • Physiology
    • Physiology (medical)


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