Evidence for the participation of cytochrome b5 in plasmalogen biosynthesis

F. Paltauf, R. A. Prough, B. S. Siler Masters, J. M. Johnston

Research output: Contribution to journalArticlepeer-review

72 Scopus citations


Using a specific antibody to rat liver cytochrome b5, ethanolamine plasmalogen (1 O alk 1' enyl 2 acyl sn glycerophosphorylethanolamine) synthesis by pork spleen microsomes is shown to require cytochrome b5. Either NADH or NADPH could serve as a source of reducing equivalents. These results provide direct evidence for the involvement of cytochrome b5 in plasmalogen biosynthesis from the corresponding 1 O alkyl ether and suggest a pathway analogous to the fatty acid desaturase system.

Original languageEnglish (US)
Pages (from-to)2661-2662
Number of pages2
JournalJournal of Biological Chemistry
Issue number8
StatePublished - 1974

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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