Using a specific antibody to rat liver cytochrome b5, ethanolamine plasmalogen (1 O alk 1' enyl 2 acyl sn glycerophosphorylethanolamine) synthesis by pork spleen microsomes is shown to require cytochrome b5. Either NADH or NADPH could serve as a source of reducing equivalents. These results provide direct evidence for the involvement of cytochrome b5 in plasmalogen biosynthesis from the corresponding 1 O alkyl ether and suggest a pathway analogous to the fatty acid desaturase system.
|Original language||English (US)|
|Number of pages||2|
|Journal||Journal of Biological Chemistry|
|State||Published - Dec 1 1974|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology