Evidence for the participation of cytochrome b5 in plasmalogen biosynthesis

F. Paltauf, R. A. Prough, B. S. Siler Masters, J. M. Johnston

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72 Scopus citations

Abstract

Using a specific antibody to rat liver cytochrome b5, ethanolamine plasmalogen (1 O alk 1' enyl 2 acyl sn glycerophosphorylethanolamine) synthesis by pork spleen microsomes is shown to require cytochrome b5. Either NADH or NADPH could serve as a source of reducing equivalents. These results provide direct evidence for the involvement of cytochrome b5 in plasmalogen biosynthesis from the corresponding 1 O alkyl ether and suggest a pathway analogous to the fatty acid desaturase system.

Original languageEnglish (US)
Pages (from-to)2661-2662
Number of pages2
JournalJournal of Biological Chemistry
Volume249
Issue number8
StatePublished - Dec 1 1974

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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    Paltauf, F., Prough, R. A., Siler Masters, B. S., & Johnston, J. M. (1974). Evidence for the participation of cytochrome b5 in plasmalogen biosynthesis. Journal of Biological Chemistry, 249(8), 2661-2662.