Evidence for the glycation hypothesis of aging from the food-restricted rodent model

E. J. Masoro, M. S. Katz, C. A. McMahan

Research output: Contribution to journalArticlepeer-review

109 Scopus citations

Abstract

Glucose has been proposed as a mediator of aging processes by means of glycation reactions resulting in advanced glycosylation end-products, thereby altering protein and DNA function. Testing this provocative concept has a high priority in gerontologic research. In this study, food restriction of rats - a procedure which markedly retards aging processes - was used to test the glycation hypothesis. Food-restricted rats were found to have a sustained plasma glucose concentration and percentage glycosylation of hemoglobin significantly lower than those of ad libitum fed rats. These findings are consistent with and provide support for the glycation hypothesis.

Original languageEnglish (US)
Pages (from-to)B20-B22
JournalJournals of Gerontology
Volume44
Issue number1
DOIs
StatePublished - Jan 1 1989

ASJC Scopus subject areas

  • Aging

Fingerprint Dive into the research topics of 'Evidence for the glycation hypothesis of aging from the food-restricted rodent model'. Together they form a unique fingerprint.

Cite this