Evidence for the Benefits of Melatonin in Cardiovascular Disease

Mohammad Tobeiha, Ameneh Jafari, Sara Fadaei, Seyed Mohammad Ali Mirazimi, Fatemeh Dashti, Atefeh Amiri, Haroon Khan, Zatollah Asemi, Russel J. Reiter, Michael R. Hamblin, Hamed Mirzaei

Research output: Contribution to journalReview articlepeer-review

38 Scopus citations


The pineal gland is a neuroendocrine gland which produces melatonin, a neuroendocrine hormone with critical physiological roles in the circadian rhythm and sleep-wake cycle. Melatonin has been shown to possess anti-oxidant activity and neuroprotective properties. Numerous studies have shown that melatonin has significant functions in cardiovascular disease, and may have anti-aging properties. The ability of melatonin to decrease primary hypertension needs to be more extensively evaluated. Melatonin has shown significant benefits in reducing cardiac pathology, and preventing the death of cardiac muscle in response to ischemia-reperfusion in rodent species. Moreover, melatonin may also prevent the hypertrophy of the heart muscle under some circumstances, which in turn would lessen the development of heart failure. Several currently used conventional drugs show cardiotoxicity as an adverse effect. Recent rodent studies have shown that melatonin acts as an anti-oxidant and is effective in suppressing heart damage mediated by pharmacologic drugs. Therefore, melatonin has been shown to have cardioprotective activity in multiple animal and human studies. Herein, we summarize the most established benefits of melatonin in the cardiovascular system with a focus on the molecular mechanisms of action.

Original languageEnglish (US)
Article number888319
JournalFrontiers in Cardiovascular Medicine
StatePublished - Jun 20 2022


  • antioxidant
  • cardiotoxicity
  • cardiovascular disease
  • melatonin
  • pathophysiology

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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