Evidence for joint action of genes on diabetes status and cvd risk factors in american indians: The strong heart family study

K. E. North, J. T. Williams, T. K. Welty, L. G. Best, E. T. Lee, R. R. Fabsitz, B. V. Howard, J. W. MacCluer

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

OBJECTIVES: Previous research among American Indians of the strong heart family study (SHFS) has demonstrated significant heritabilities for CVD risk factors and implicated diabetes as an important predictor of several of the phenotypes. Moreover, we recently demonstrated that genetic effects on CVD risk factors differed in diabetic and nondiabetic individuals. In this paper, we investigated whether a significant genetic influence on diabetes status could be identified, and whether there is evidence for joint action of genes on diabetes status and related CVD risk factors. METHODS AND RESULTS: Approximately 950 men and women, age 18 or older, in 32 extended families, were examined between 1997 and 1999. We estimated the effects of genes and environmental covariates on diabetes status using a threshold model and a maximum likelihood variance component approach. Diabetes status exhibited a residual heritability of 22% (h2 = 0.22). We also estimated the genetic and environmental correlations between diabetes susceptibility and eight risk factors for CVD. All eight CVD risk factors displayed significant genetic correlations with diabetes status (BMI (ρG = 0.55), fibrinogen (ρG = 0.40), HDL-C (ρG= -0.37), In triglycerides (ρG = 0.65), FAT (ρG = 0.38), PAI-1 (ρG = 0.67), SBP (ρG = 0.57), and WHR (ρG = 0.58)). Three of eight traits (HDL-C (ρE = -0.32), In triglycerides (ρE = 0.33), and fibrinogen (ρE = 0.20)) displayed significant environmental correlations with diabetes status. CONCLUSIONS: These findings suggest that in the context of a high prevalence of diabetes, still unidentified diabetes genes may play an important role in influencing variation in CVD risk factors.

Original languageEnglish (US)
Pages (from-to)491-497
Number of pages7
JournalInternational Journal of Obesity
Volume27
Issue number4
DOIs
StatePublished - Apr 1 2003
Externally publishedYes

Fingerprint

family studies
North American Indians
American Indians
diabetes
risk factors
heart
Genes
genes
Fibrinogen
Triglycerides
fibrinogen
Plasminogen Activator Inhibitor 1
heritability
triacylglycerols
extended families
Phenotype
genetic correlation
Research
phenotype

Keywords

  • American Indians
  • CVD risk factors
  • Diabetes status
  • Pleiotropy
  • Strong heart family study

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Public Health, Environmental and Occupational Health
  • Endocrinology
  • Food Science
  • Endocrinology, Diabetes and Metabolism

Cite this

North, K. E., Williams, J. T., Welty, T. K., Best, L. G., Lee, E. T., Fabsitz, R. R., ... MacCluer, J. W. (2003). Evidence for joint action of genes on diabetes status and cvd risk factors in american indians: The strong heart family study. International Journal of Obesity, 27(4), 491-497. https://doi.org/10.1038/sj.ijo.0802261

Evidence for joint action of genes on diabetes status and cvd risk factors in american indians : The strong heart family study. / North, K. E.; Williams, J. T.; Welty, T. K.; Best, L. G.; Lee, E. T.; Fabsitz, R. R.; Howard, B. V.; MacCluer, J. W.

In: International Journal of Obesity, Vol. 27, No. 4, 01.04.2003, p. 491-497.

Research output: Contribution to journalArticle

North, KE, Williams, JT, Welty, TK, Best, LG, Lee, ET, Fabsitz, RR, Howard, BV & MacCluer, JW 2003, 'Evidence for joint action of genes on diabetes status and cvd risk factors in american indians: The strong heart family study', International Journal of Obesity, vol. 27, no. 4, pp. 491-497. https://doi.org/10.1038/sj.ijo.0802261
North, K. E. ; Williams, J. T. ; Welty, T. K. ; Best, L. G. ; Lee, E. T. ; Fabsitz, R. R. ; Howard, B. V. ; MacCluer, J. W. / Evidence for joint action of genes on diabetes status and cvd risk factors in american indians : The strong heart family study. In: International Journal of Obesity. 2003 ; Vol. 27, No. 4. pp. 491-497.
@article{d728cf2e747f4169b6f88ecc728da350,
title = "Evidence for joint action of genes on diabetes status and cvd risk factors in american indians: The strong heart family study",
abstract = "OBJECTIVES: Previous research among American Indians of the strong heart family study (SHFS) has demonstrated significant heritabilities for CVD risk factors and implicated diabetes as an important predictor of several of the phenotypes. Moreover, we recently demonstrated that genetic effects on CVD risk factors differed in diabetic and nondiabetic individuals. In this paper, we investigated whether a significant genetic influence on diabetes status could be identified, and whether there is evidence for joint action of genes on diabetes status and related CVD risk factors. METHODS AND RESULTS: Approximately 950 men and women, age 18 or older, in 32 extended families, were examined between 1997 and 1999. We estimated the effects of genes and environmental covariates on diabetes status using a threshold model and a maximum likelihood variance component approach. Diabetes status exhibited a residual heritability of 22{\%} (h2 = 0.22). We also estimated the genetic and environmental correlations between diabetes susceptibility and eight risk factors for CVD. All eight CVD risk factors displayed significant genetic correlations with diabetes status (BMI (ρG = 0.55), fibrinogen (ρG = 0.40), HDL-C (ρG= -0.37), In triglycerides (ρG = 0.65), FAT (ρG = 0.38), PAI-1 (ρG = 0.67), SBP (ρG = 0.57), and WHR (ρG = 0.58)). Three of eight traits (HDL-C (ρE = -0.32), In triglycerides (ρE = 0.33), and fibrinogen (ρE = 0.20)) displayed significant environmental correlations with diabetes status. CONCLUSIONS: These findings suggest that in the context of a high prevalence of diabetes, still unidentified diabetes genes may play an important role in influencing variation in CVD risk factors.",
keywords = "American Indians, CVD risk factors, Diabetes status, Pleiotropy, Strong heart family study",
author = "North, {K. E.} and Williams, {J. T.} and Welty, {T. K.} and Best, {L. G.} and Lee, {E. T.} and Fabsitz, {R. R.} and Howard, {B. V.} and MacCluer, {J. W.}",
year = "2003",
month = "4",
day = "1",
doi = "10.1038/sj.ijo.0802261",
language = "English (US)",
volume = "27",
pages = "491--497",
journal = "International Journal of Obesity",
issn = "0307-0565",
publisher = "Nature Publishing Group",
number = "4",

}

TY - JOUR

T1 - Evidence for joint action of genes on diabetes status and cvd risk factors in american indians

T2 - The strong heart family study

AU - North, K. E.

AU - Williams, J. T.

AU - Welty, T. K.

AU - Best, L. G.

AU - Lee, E. T.

AU - Fabsitz, R. R.

AU - Howard, B. V.

AU - MacCluer, J. W.

PY - 2003/4/1

Y1 - 2003/4/1

N2 - OBJECTIVES: Previous research among American Indians of the strong heart family study (SHFS) has demonstrated significant heritabilities for CVD risk factors and implicated diabetes as an important predictor of several of the phenotypes. Moreover, we recently demonstrated that genetic effects on CVD risk factors differed in diabetic and nondiabetic individuals. In this paper, we investigated whether a significant genetic influence on diabetes status could be identified, and whether there is evidence for joint action of genes on diabetes status and related CVD risk factors. METHODS AND RESULTS: Approximately 950 men and women, age 18 or older, in 32 extended families, were examined between 1997 and 1999. We estimated the effects of genes and environmental covariates on diabetes status using a threshold model and a maximum likelihood variance component approach. Diabetes status exhibited a residual heritability of 22% (h2 = 0.22). We also estimated the genetic and environmental correlations between diabetes susceptibility and eight risk factors for CVD. All eight CVD risk factors displayed significant genetic correlations with diabetes status (BMI (ρG = 0.55), fibrinogen (ρG = 0.40), HDL-C (ρG= -0.37), In triglycerides (ρG = 0.65), FAT (ρG = 0.38), PAI-1 (ρG = 0.67), SBP (ρG = 0.57), and WHR (ρG = 0.58)). Three of eight traits (HDL-C (ρE = -0.32), In triglycerides (ρE = 0.33), and fibrinogen (ρE = 0.20)) displayed significant environmental correlations with diabetes status. CONCLUSIONS: These findings suggest that in the context of a high prevalence of diabetes, still unidentified diabetes genes may play an important role in influencing variation in CVD risk factors.

AB - OBJECTIVES: Previous research among American Indians of the strong heart family study (SHFS) has demonstrated significant heritabilities for CVD risk factors and implicated diabetes as an important predictor of several of the phenotypes. Moreover, we recently demonstrated that genetic effects on CVD risk factors differed in diabetic and nondiabetic individuals. In this paper, we investigated whether a significant genetic influence on diabetes status could be identified, and whether there is evidence for joint action of genes on diabetes status and related CVD risk factors. METHODS AND RESULTS: Approximately 950 men and women, age 18 or older, in 32 extended families, were examined between 1997 and 1999. We estimated the effects of genes and environmental covariates on diabetes status using a threshold model and a maximum likelihood variance component approach. Diabetes status exhibited a residual heritability of 22% (h2 = 0.22). We also estimated the genetic and environmental correlations between diabetes susceptibility and eight risk factors for CVD. All eight CVD risk factors displayed significant genetic correlations with diabetes status (BMI (ρG = 0.55), fibrinogen (ρG = 0.40), HDL-C (ρG= -0.37), In triglycerides (ρG = 0.65), FAT (ρG = 0.38), PAI-1 (ρG = 0.67), SBP (ρG = 0.57), and WHR (ρG = 0.58)). Three of eight traits (HDL-C (ρE = -0.32), In triglycerides (ρE = 0.33), and fibrinogen (ρE = 0.20)) displayed significant environmental correlations with diabetes status. CONCLUSIONS: These findings suggest that in the context of a high prevalence of diabetes, still unidentified diabetes genes may play an important role in influencing variation in CVD risk factors.

KW - American Indians

KW - CVD risk factors

KW - Diabetes status

KW - Pleiotropy

KW - Strong heart family study

UR - http://www.scopus.com/inward/record.url?scp=0037396444&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037396444&partnerID=8YFLogxK

U2 - 10.1038/sj.ijo.0802261

DO - 10.1038/sj.ijo.0802261

M3 - Article

C2 - 12698956

AN - SCOPUS:0037396444

VL - 27

SP - 491

EP - 497

JO - International Journal of Obesity

JF - International Journal of Obesity

SN - 0307-0565

IS - 4

ER -