Evidence for distinct genetic effects on obesity and lipid-related CVD risk factors in diabetic compared to nondiabetic American Indians: The Strong Heart Family Study

Kari E. North, Jean W. MacCluer, Jeff T. Williams, Thomas K. Welty, Lyle G. Best, Elisa T. Lee, Richard R. Fabsitz, Barbara V. Howard

    Research output: Contribution to journalArticlepeer-review

    11 Scopus citations

    Abstract

    Background. The relationship between diabetes and increased cardiovasular disease (CVD) risk is well established. Previous data from the Strong Heart Family Study (SHFS) have demonstrated significant heritabilities for CVD risk factors and implicated diabetes as an important predictor of several of the phenotypes in three large groups of American Indians in Arizona (AZ), Oklahoma (OK), and the Dakotas (DK). However, the genetic architecture of this relationship is not well understood. The purpose of the present paper is to determine whether the genetic effects on CVD risk factors in the SHFS are different in diabetic and nondiabetic individuals. Methods. Approximately 950 men and women, 18 years or older, in 32 extended families, were examined between 1997 and 1999. Interaction between genotype and diabetes status was estimated for nine CVD risk factors [body fat mass (FAT), body mass index (BMI), high-density lipoprotein cholesterol (HDL-C), log-transformed fibrinogen, log-transformed triglycerides, log-transformed urinary albumin: creatinine ratio (LACR), plasminogen activator inhibitor 1 (PAI-1), systolic blood pressure (SBP), and waist-to-hip ratio (WHR)], using a maximum likelihood variance decomposition technique. Results. We found evidence that genetic factors influencing BMI, FAT, log-transformed triglycerides, HDL-C, and WHR are differentially expressed in individuals with diabetes compared to those without diabetes. Conclusion. Thus, in the environmental and genetic milieu of diabetes, there may be distinct genetic determinants of various CVD risk factors.

    Original languageEnglish (US)
    Pages (from-to)140-147
    Number of pages8
    JournalDiabetes/Metabolism Research and Reviews
    Volume19
    Issue number2
    DOIs
    StatePublished - Mar 2003

    Keywords

    • American Indians
    • CVD risk factors
    • Diabetes
    • Genetic effects
    • Strong Heart Family Study

    ASJC Scopus subject areas

    • Internal Medicine
    • Endocrinology, Diabetes and Metabolism
    • Endocrinology

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