Evelynin, a cytotoxic benzoquinone-type retro -dihydrochalcone from Tacca chantrieri

Jiangnan Peng; Evelyn M. Jackson; David J. Babinski; April L. Risinger; Gregory Helms; Doug E. Frantz; Susan L. Mooberry

doi:10.1021/np100350s

Evelynin, a cytotoxic benzoquinone-type retro -dihydrochalcone from Tacca chantrieri

Jiangnan Peng
, Evelyn M. Jackson
, David J. Babinski
, April L. Risinger
, Gregory Helms
, Doug E. Frantz
, Susan L. Mooberry

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

A new benzoquinone-type retro-dihydrochalcone, named evelynin, was isolated from the roots and rhizomes of Tacca chantrieri. The structure was elucidated on the basis of the analysis of spectroscopic data and confirmed by a simple one-step total synthesis. Evelynin exhibited cytotoxicity against four human cancer cell lines, MDA-MB-435 melanoma, MDA-MB-231 breast, PC-3 prostate, and HeLa cervical carcinoma cells, with IC₅₀ values of 4.1, 3.9, 4.7, and 6.3 μM, respectively.

Original language	English (US)
Pages (from-to)	1590-1592
Number of pages	3
Journal	Journal of Natural Products
Volume	73
Issue number	9
DOIs	https://doi.org/10.1021/np100350s
State	Published - Sep 24 2010

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np100350s

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title = "Evelynin, a cytotoxic benzoquinone-type retro -dihydrochalcone from Tacca chantrieri",

abstract = "A new benzoquinone-type retro-dihydrochalcone, named evelynin, was isolated from the roots and rhizomes of Tacca chantrieri. The structure was elucidated on the basis of the analysis of spectroscopic data and confirmed by a simple one-step total synthesis. Evelynin exhibited cytotoxicity against four human cancer cell lines, MDA-MB-435 melanoma, MDA-MB-231 breast, PC-3 prostate, and HeLa cervical carcinoma cells, with IC50 values of 4.1, 3.9, 4.7, and 6.3 μM, respectively.",

author = "Jiangnan Peng and Jackson, \{Evelyn M.\} and Babinski, \{David J.\} and Risinger, \{April L.\} and Gregory Helms and Frantz, \{Doug E.\} and Mooberry, \{Susan L.\}",

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AU - Peng, Jiangnan

AU - Jackson, Evelyn M.

AU - Babinski, David J.

AU - Risinger, April L.

AU - Helms, Gregory

AU - Frantz, Doug E.

AU - Mooberry, Susan L.

PY - 2010/9/24

Y1 - 2010/9/24

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AB - A new benzoquinone-type retro-dihydrochalcone, named evelynin, was isolated from the roots and rhizomes of Tacca chantrieri. The structure was elucidated on the basis of the analysis of spectroscopic data and confirmed by a simple one-step total synthesis. Evelynin exhibited cytotoxicity against four human cancer cell lines, MDA-MB-435 melanoma, MDA-MB-231 breast, PC-3 prostate, and HeLa cervical carcinoma cells, with IC50 values of 4.1, 3.9, 4.7, and 6.3 μM, respectively.

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JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 9

ER -

Evelynin, a cytotoxic benzoquinone-type retro -dihydrochalcone from Tacca chantrieri

Abstract

ASJC Scopus subject areas

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