Evelynin, a cytotoxic benzoquinone-type retro -dihydrochalcone from Tacca chantrieri

Jiangnan Peng, Evelyn M. Jackson, David J. Babinski, April L. Risinger, Gregory Helms, Doug E. Frantz, Susan L. Mooberry

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

A new benzoquinone-type retro-dihydrochalcone, named evelynin, was isolated from the roots and rhizomes of Tacca chantrieri. The structure was elucidated on the basis of the analysis of spectroscopic data and confirmed by a simple one-step total synthesis. Evelynin exhibited cytotoxicity against four human cancer cell lines, MDA-MB-435 melanoma, MDA-MB-231 breast, PC-3 prostate, and HeLa cervical carcinoma cells, with IC50 values of 4.1, 3.9, 4.7, and 6.3 μM, respectively.

Original languageEnglish (US)
Pages (from-to)1590-1592
Number of pages3
JournalJournal of Natural Products
Volume73
Issue number9
DOIs
StatePublished - Sep 24 2010

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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