Evaluation on lung cancer patients' four-dimensional treatment plans utilizing biologically effective uniform dose

Fan Chi Su, Chengyu Shi, Panayiotis Mavroidis, Virginia Goytia, Richard Crownover, Prema Rassiah-Szegedi, Dimos Baltas, Niko Papanikolaou

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Four-dimensional (4D) radiotherapy is considered to be a feasible and ideal solution to accommodate intrafractional respiratory motion during conformal radiation therapy. With explicit inclusion of the temporal changes in anatomy during the imaging, planning, and delivery of radiotherapy, 4D treatment planning in principle provides better dose conformity. However, the clinical benefits of developing 4D treatment plans in terms of tumor control rate and normal tissue complication probability as compared to other treatment plans based on CT images of a fixed respiratory phase remain mostly unproven. The aim of our study is to comprehensively evaluate 4D treatment planning for nine lung tumor cases with both physical and biological measures using biologically effective uniform dose (Dcombining double overline) together with complication-free tumor control probability, P+. Based on the examined lung cancer patients and PTV margin applied, we found similar but not identical curves of DVH, and slightly different mean doses in tumor and normal tissues in all cases when comparing 4D, P0% and P50% plans. When it comes to biological evaluations, we did not observe definitively PTV size dependence in P+ among these nine lung cancer patients with various sizes of PTV. Moreover, it is not necessary that 4D plans would have better target coverage or higher P+ as compared to a fixed phase IMRT plan.

Original languageEnglish (US)
Title of host publicationWorld Congress on Medical Physics and Biomedical Engineering
Subtitle of host publicationRadiation Oncology
Pages303-306
Number of pages4
Edition1
DOIs
StatePublished - Dec 1 2009
EventWorld Congress on Medical Physics and Biomedical Engineering: Radiation Oncology - Munich, Germany
Duration: Sep 7 2009Sep 12 2009

Publication series

NameIFMBE Proceedings
Number1
Volume25
ISSN (Print)1680-0737

Other

OtherWorld Congress on Medical Physics and Biomedical Engineering: Radiation Oncology
CountryGermany
CityMunich
Period9/7/099/12/09

Keywords

  • Biologically effective uniform dose
  • Four-dimensional treatment planning
  • Organ motion
  • Radiobiological objectives
  • Treatment planning

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering

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