Evaluation of VT-1161 for treatment of coccidioidomycosis in murine infection models

Lisa F. Shubitz, Hien T. Trinh, John N. Galgiani, Maria L. Lewis, Annette W. Fothergill, Nathan Wiederhold, Bridget M. Barker, Eric R G Lewis, Adina L. Doyle, William J. Hoekstra, Robert J. Schotzinger, Edward P. Garvey

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Coccidioidomycosis, or valley fever, is a growing health concern endemic to the southwestern United States. Safer, more effective, and more easily administered drugs are needed especially for severe, chronic, or unresponsive infections. The novel fungal CYP51 inhibitor VT-1161 demonstrated in vitro antifungal activity, with MIC50 and MIC90 values of 1 and 2 μg/ml, respectively, against 52 Coccidioides clinical isolates. In the initial animal study, oral doses of 10 and 50 mg/kg VT-1161 significantly reduced fungal burdens and increased survival time in a lethal respiratory model in comparison with treatment with a placebo (P

Original languageEnglish (US)
Pages (from-to)7249-7254
Number of pages6
JournalAntimicrobial Agents and Chemotherapy
Volume59
Issue number12
DOIs
StatePublished - Dec 1 2015

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Infectious Diseases

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    Shubitz, L. F., Trinh, H. T., Galgiani, J. N., Lewis, M. L., Fothergill, A. W., Wiederhold, N., Barker, B. M., Lewis, E. R. G., Doyle, A. L., Hoekstra, W. J., Schotzinger, R. J., & Garvey, E. P. (2015). Evaluation of VT-1161 for treatment of coccidioidomycosis in murine infection models. Antimicrobial Agents and Chemotherapy, 59(12), 7249-7254. https://doi.org/10.1128/AAC.00593-15