Evaluation of time to detection of Mycobacterium tuberculosis in broth culture as a determinant for end points in treatment trials

Marc Weiner, Thomas J. Prihoda, William Burman, John L. Johnson, Stefan Goldberg, Nesri Padayatchi, Paula Duran, Melissa Engle, Grace Muzanye, Roy D. Mugerwa, A. Willem Sturm

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Time to detection of Mycobacterium tuberculosis in broth culture was examined for utility as a treatment efficacy end point. Of 146 patients in a phase IIB trial, a decreased mean time to detection was found in 5 with treatment failure. Time to detection in an analysis-of-covariance model was associated with lung cavities, less intensive treatment, and differences in the bactericidal effects of treatment regimens.

Original languageEnglish (US)
Pages (from-to)4370-4376
Number of pages7
JournalJournal of clinical microbiology
Volume48
Issue number12
DOIs
StatePublished - Dec 2010

ASJC Scopus subject areas

  • Microbiology (medical)

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