Evaluation of the Semmes–Weinstein filaments and a questionnaire to assess chemotherapy-induced peripheral neuropathy

Delma Aurélia da Silva Simão, Antônio Lúcio Teixeira, Raissa Silva Souza, Elenice Dias Ribeiro de Paula Lima

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Objective: This study aims to assess the use of Semmes–Weinstein monofilaments (SWMs) and of the Chemotherapy-Induced Neurotoxicity Questionnaire (CINQ) in the detection of chemotherapy-induced peripheral neuropathy (CIPN).Method: It is a comparative and cross-sectional study performed in a philanthropic general hospital, located in the state of Minas Gerais, Brazil. One hundred seventeen individuals have participated in this study; they were divided into two groups: patients (n = 87) treated with oxaliplatin, paclitaxel, or docetaxel and controls (n = 30) without malignant disease.Results: There were statistically significant differences between groups for all symptoms assessed by means of the CINQ. Lower limbs were more severely affected. Patients had increased frequency and severity of changes in all points assessed with SWM compared with controls. In the analyses of concordance between CINQ and SWM, kappa = 0.320 (p < 0.001) was obtained, and there was a moderate and positive correlation (ρ = 0.357; p < 0.001).Conclusion: CINQ and SWM may be valid tools for diagnosing CIPN in oncology practice. SWM may identify subclinical CIPN.

Original languageEnglish (US)
Pages (from-to)2767-2773
Number of pages7
JournalSupportive Care in Cancer
Volume22
Issue number10
DOIs
StatePublished - Oct 2014
Externally publishedYes

Keywords

  • Adverse effects
  • Cancer
  • Chemotherapy
  • Drug therapy
  • Neuropathy

ASJC Scopus subject areas

  • Oncology

Fingerprint

Dive into the research topics of 'Evaluation of the Semmes–Weinstein filaments and a questionnaire to assess chemotherapy-induced peripheral neuropathy'. Together they form a unique fingerprint.

Cite this