Evaluation of the efficacies of amphotericin B, posaconazole, voriconazole, and anidulafungin in a murine disseminated infection by the emerging opportunistic fungus Sarocladium (Acremonium) kiliense

Fabiola Fernández-Silva, Javier Capilla, Emilio Mayayo, Deanna A. Sutton, Pilar Hernández, Josep Guarro

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

We evaluated and compared the efficacies of different antifungal drugs against Sarocladium kiliense (formerly Acremonium kiliense), a clinically relevant opportunistic fungus, in a murine model of systemic infection. Three clinical strains of this fungus were tested, and the therapy administered was as follows: posaconazole at 20 mg/kg of body weight (twice daily), voriconazole at 40 mg/kg, anidulafungin at 10 mg/kg, or amphotericin B at 0.8 mg/kg. The efficacy was evaluated by prolonged animal survival, tissue burden reduction, and (1→3)-β-D-glucan serum levels. In general, the four antifungal drugs showed high MICs and poor in vitro activity. The efficacy of the different treatments was only modest, since survival rates were never higher than 40% and no drug was able to reduce fungal load in all the organs for the three strains tested. Posaconazole, in spite of its high MICs (≥16 μg/ml), showed the highest efficacy. The (1→3)-β-D-glucan serum levels were equally reduced by all drugs evaluated.

Original languageEnglish (US)
Pages (from-to)6265-6269
Number of pages5
JournalAntimicrobial Agents and Chemotherapy
Volume57
Issue number12
DOIs
StatePublished - Dec 2013

Fingerprint

anidulafungin
Acremonium
Opportunistic Infections
Amphotericin B
Fungi
Pharmaceutical Preparations
Tissue Survival
Serum
Body Weight
posaconazole
Voriconazole
Infection

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Infectious Diseases

Cite this

Evaluation of the efficacies of amphotericin B, posaconazole, voriconazole, and anidulafungin in a murine disseminated infection by the emerging opportunistic fungus Sarocladium (Acremonium) kiliense. / Fernández-Silva, Fabiola; Capilla, Javier; Mayayo, Emilio; Sutton, Deanna A.; Hernández, Pilar; Guarro, Josep.

In: Antimicrobial Agents and Chemotherapy, Vol. 57, No. 12, 12.2013, p. 6265-6269.

Research output: Contribution to journalArticle

Fernández-Silva, Fabiola ; Capilla, Javier ; Mayayo, Emilio ; Sutton, Deanna A. ; Hernández, Pilar ; Guarro, Josep. / Evaluation of the efficacies of amphotericin B, posaconazole, voriconazole, and anidulafungin in a murine disseminated infection by the emerging opportunistic fungus Sarocladium (Acremonium) kiliense. In: Antimicrobial Agents and Chemotherapy. 2013 ; Vol. 57, No. 12. pp. 6265-6269.
@article{d964f3fed473451da403cb724d58e675,
title = "Evaluation of the efficacies of amphotericin B, posaconazole, voriconazole, and anidulafungin in a murine disseminated infection by the emerging opportunistic fungus Sarocladium (Acremonium) kiliense",
abstract = "We evaluated and compared the efficacies of different antifungal drugs against Sarocladium kiliense (formerly Acremonium kiliense), a clinically relevant opportunistic fungus, in a murine model of systemic infection. Three clinical strains of this fungus were tested, and the therapy administered was as follows: posaconazole at 20 mg/kg of body weight (twice daily), voriconazole at 40 mg/kg, anidulafungin at 10 mg/kg, or amphotericin B at 0.8 mg/kg. The efficacy was evaluated by prolonged animal survival, tissue burden reduction, and (1→3)-β-D-glucan serum levels. In general, the four antifungal drugs showed high MICs and poor in vitro activity. The efficacy of the different treatments was only modest, since survival rates were never higher than 40{\%} and no drug was able to reduce fungal load in all the organs for the three strains tested. Posaconazole, in spite of its high MICs (≥16 μg/ml), showed the highest efficacy. The (1→3)-β-D-glucan serum levels were equally reduced by all drugs evaluated.",
author = "Fabiola Fern{\'a}ndez-Silva and Javier Capilla and Emilio Mayayo and Sutton, {Deanna A.} and Pilar Hern{\'a}ndez and Josep Guarro",
year = "2013",
month = "12",
doi = "10.1128/AAC.01484-13",
language = "English (US)",
volume = "57",
pages = "6265--6269",
journal = "Antimicrobial Agents and Chemotherapy",
issn = "0066-4804",
publisher = "American Society for Microbiology",
number = "12",

}

TY - JOUR

T1 - Evaluation of the efficacies of amphotericin B, posaconazole, voriconazole, and anidulafungin in a murine disseminated infection by the emerging opportunistic fungus Sarocladium (Acremonium) kiliense

AU - Fernández-Silva, Fabiola

AU - Capilla, Javier

AU - Mayayo, Emilio

AU - Sutton, Deanna A.

AU - Hernández, Pilar

AU - Guarro, Josep

PY - 2013/12

Y1 - 2013/12

N2 - We evaluated and compared the efficacies of different antifungal drugs against Sarocladium kiliense (formerly Acremonium kiliense), a clinically relevant opportunistic fungus, in a murine model of systemic infection. Three clinical strains of this fungus were tested, and the therapy administered was as follows: posaconazole at 20 mg/kg of body weight (twice daily), voriconazole at 40 mg/kg, anidulafungin at 10 mg/kg, or amphotericin B at 0.8 mg/kg. The efficacy was evaluated by prolonged animal survival, tissue burden reduction, and (1→3)-β-D-glucan serum levels. In general, the four antifungal drugs showed high MICs and poor in vitro activity. The efficacy of the different treatments was only modest, since survival rates were never higher than 40% and no drug was able to reduce fungal load in all the organs for the three strains tested. Posaconazole, in spite of its high MICs (≥16 μg/ml), showed the highest efficacy. The (1→3)-β-D-glucan serum levels were equally reduced by all drugs evaluated.

AB - We evaluated and compared the efficacies of different antifungal drugs against Sarocladium kiliense (formerly Acremonium kiliense), a clinically relevant opportunistic fungus, in a murine model of systemic infection. Three clinical strains of this fungus were tested, and the therapy administered was as follows: posaconazole at 20 mg/kg of body weight (twice daily), voriconazole at 40 mg/kg, anidulafungin at 10 mg/kg, or amphotericin B at 0.8 mg/kg. The efficacy was evaluated by prolonged animal survival, tissue burden reduction, and (1→3)-β-D-glucan serum levels. In general, the four antifungal drugs showed high MICs and poor in vitro activity. The efficacy of the different treatments was only modest, since survival rates were never higher than 40% and no drug was able to reduce fungal load in all the organs for the three strains tested. Posaconazole, in spite of its high MICs (≥16 μg/ml), showed the highest efficacy. The (1→3)-β-D-glucan serum levels were equally reduced by all drugs evaluated.

UR - http://www.scopus.com/inward/record.url?scp=84887451723&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84887451723&partnerID=8YFLogxK

U2 - 10.1128/AAC.01484-13

DO - 10.1128/AAC.01484-13

M3 - Article

C2 - 24100490

AN - SCOPUS:84887451723

VL - 57

SP - 6265

EP - 6269

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

SN - 0066-4804

IS - 12

ER -