Evaluation of the anxiolytic properties of Tetrahydropalmatine, a Corydalis yanhusuo compound, in the male Sprague-Dawley rat

Herman Henkes, Michael Franz, Orin Kendall, Jacqueline Monroe, Anna Legaspi, Joann LeDoux, Christopher Haese, Daniel Williams, Suzanne McCall, Arthur Don Johnson, Thomas E. Ceremuga

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

The purpose of this study was to investigate the anxiolytic effects of tetrahydropalmatine (THP) and its potential interaction with the benzodiazepine binding site on the γ-aminobutyric acid (GABA A) receptor in the male Sprague-Dawley rat. Tetrahydropalmatine (THP), an active component isolated from the Chinese herbal plant Corydalis yanhusuo, is used in Asia for its analgesic, sedative, and hypnotic properties during herbal therapy. Fifty-five rats were assigned to 1 of 5 groups with 11 rats per group: 1) control (vehicle), 2) THP, 3) midazolam, 4) midazolam with THP, and 5) flumazenil with THP. In this study, the elevated plus-maze measured the behavioral components of anxiety and motor movements. The data were analyzed using a 2-tailed multivariate analysis of variance to determine if a significant difference existed followed by the least significant difference post hoc test. The findings suggest that THP, 25 mg/kg, given via intraperitoneal injection, results in significant anxiolysis and decreased motor movements. Furthermore, flumazenil, 3 mg/kg, does not fully antagonize the effects of THP.

Original languageEnglish (US)
Pages (from-to)S75-S80
JournalAANA Journal
Volume79
Issue numberSUPPL. 4
StatePublished - Aug 1 2011
Externally publishedYes

Keywords

  • Anxiolysis
  • Corydalis yanhusuo
  • Elevated plus-maze
  • Sprague-Dawley rat
  • Tetrahydropalmatine

ASJC Scopus subject areas

  • Medical–Surgical
  • Advanced and Specialized Nursing
  • Anesthesiology and Pain Medicine

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