Evaluation of the anxiolytic properties of Tetrahydropalmatine, a Corydalis yanhusuo compound, in the male Sprague-Dawley rat

Herman Henkes, Michael Franz, Orin Kendall, Jacqueline Monroe, Anna Legaspi, Joann LeDoux, Christopher Haese, Daniel Williams, Suzanne McCall, Arthur Don Johnson, Thomas E. Ceremuga

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

The purpose of this study was to investigate the anxiolytic effects of tetrahydropalmatine (THP) and its potential interaction with the benzodiazepine binding site on the γ-aminobutyric acid (GABA A) receptor in the male Sprague-Dawley rat. Tetrahydropalmatine (THP), an active component isolated from the Chinese herbal plant Corydalis yanhusuo, is used in Asia for its analgesic, sedative, and hypnotic properties during herbal therapy. Fifty-five rats were assigned to 1 of 5 groups with 11 rats per group: 1) control (vehicle), 2) THP, 3) midazolam, 4) midazolam with THP, and 5) flumazenil with THP. In this study, the elevated plus-maze measured the behavioral components of anxiety and motor movements. The data were analyzed using a 2-tailed multivariate analysis of variance to determine if a significant difference existed followed by the least significant difference post hoc test. The findings suggest that THP, 25 mg/kg, given via intraperitoneal injection, results in significant anxiolysis and decreased motor movements. Furthermore, flumazenil, 3 mg/kg, does not fully antagonize the effects of THP.

Original languageEnglish (US)
Pages (from-to)S75-S80
JournalAANA Journal
Volume79
Issue numberSUPPL. 4
StatePublished - Aug 1 2011
Externally publishedYes

Keywords

  • Anxiolysis
  • Corydalis yanhusuo
  • Elevated plus-maze
  • Sprague-Dawley rat
  • Tetrahydropalmatine

ASJC Scopus subject areas

  • Medical–Surgical
  • Advanced and Specialized Nursing
  • Anesthesiology and Pain Medicine

Fingerprint Dive into the research topics of 'Evaluation of the anxiolytic properties of Tetrahydropalmatine, a Corydalis yanhusuo compound, in the male Sprague-Dawley rat'. Together they form a unique fingerprint.

  • Cite this

    Henkes, H., Franz, M., Kendall, O., Monroe, J., Legaspi, A., LeDoux, J., Haese, C., Williams, D., McCall, S., Johnson, A. D., & Ceremuga, T. E. (2011). Evaluation of the anxiolytic properties of Tetrahydropalmatine, a Corydalis yanhusuo compound, in the male Sprague-Dawley rat. AANA Journal, 79(SUPPL. 4), S75-S80.