Evaluation of the anti-SARS-CoV-2 properties of essential oils and aromatic extracts

Daniel Jan Strub, Michał Talma, Maria Strub, Wioletta Rut, Mikolaj Zmudzinski, Władysław Brud, Johan Neyts, Laura Vangeel, Linlin Zhang, Xinyuanyuan Sun, Zongyang Lv, Digant Nayak, Shaun K. Olsen, Rolf Hilgenfeld, Dirk Jochmans, Marcin Drąg

Research output: Contribution to journalArticlepeer-review

Abstract

Essential oils and aromatic extracts (oleoresins, absolutes, concretes, resinoids) are often used as food flavorings and constituents of fragrance compositions. The flavor and fragrance industry observed significant growth in the sales of some natural materials during the COVID-19 outbreak. Some companies worldwide are making false claims regarding the effectiveness of their essential oils or blends (or indirectly point toward this conclusion) against coronaviruses, even though the available data on the activity of plant materials against highly pathogenic human coronaviruses are very scarce. Our exploratory study aimed to develop pioneering knowledge and provide the first experimental results on the inhibitory properties of hundreds of flavor and fragrance materials against SARS-CoV-2 main and papain-like proteases and the antiviral potential of the most active protease inhibitors. As essential oils are volatile products, they could provide an interesting therapeutic strategy for subsidiary inhalation in the long term.

Original languageEnglish (US)
Article number14230
JournalScientific reports
Volume12
Issue number1
DOIs
StatePublished - Dec 2022

ASJC Scopus subject areas

  • General

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